Louisville Cardinals vs Duke Blue Devils NCAAB Betting Prediction

Louisville Cardinals vs Duke Blue Prediction 3/15/2025

The Louisville Cardinals (27-6) travel to face off against the Duke Blue Devils (30-3) on Saturday, March 15th. This game will be played at Spectrum Center in Charlotte and televised on ESPN. Both team’s come into this one having won their previous games. Tip-off is set for 8:30 ET.

Louisville Cardinals vs Duke Blue Devils

The Cardinals Are Coming Off A Win

Louisville Cardinals Recent Game/Games

The Cardinals improved to 27-6 this season with a 76-73 win over Clemson on Friday, March 14th. Louisville, who were +2.5 point underdogs, not only won but also covered the spread.

Louisville led 33-28 at halftime and scored 43 points in the 2nd half while allowing 45. The total points for the game were 149, going over the O/U line of 141.5.

The Blue Devils Are Coming Off A Win

Duke improved to 30-3 on the season with a 74-71 win over North Carolina on Friday. The Blue Devils were favored by 7 points but didn’t cover the spread, and the game’s total points of 145 fell short of the 153.5 O/U line.

Duke looked dominant early, leading 45-24 at halftime, but allowed 47 points in the 2nd half while scoring just 29 themselves, making the game much closer than expected.

Cardinals Offense Breakdown

In their last game, Louisville put up 76 points, shooting 43.6% from the field. They hit 54.5% of their two-point attempts, but struggled from beyond the arc, going just 6-for-22 (27.3%).

At the free-throw line, the Cardinals connected on 81.5% of their attempts, making 22 of 27. Chase Hunter led the way with 23 points, hitting 3 of 6 from deep, while J’Vonne Hadley added 20 points, shooting 66.7% overall and from three-point range.

Blue Devils Offense Breakdown

Duke’s offense put up 74 points in their last game, shooting 49.1% from the field with an effective field goal percentage of 54.5%. They excelled inside, hitting 66.7% of their two-point attempts (22/33), but struggled from beyond the arc, connecting on just 5 of 22 threes (22.7%).

Ven-Allen Lubin led the way with 20 points and 10 rebounds, shooting 8 of 11 from the field. Kon Knueppel added 17 points, hitting 3 of 5 from deep, while Elliot Cadeau was perfect from three, making all 3 of his attempts and finishing with 15 points and 5 assists.

Cardinals Team Defense

Louisville’s defense gave up 73 points in their last game, with opponents shooting 43% from the field on 24 of 55 attempts. Inside the arc, they allowed 54% shooting, with 18 two-point baskets made.

From three-point range, Louisville’s defense held their opponents to 27% shooting, with just 6 threes made on 22 attempts. They also sent them to the free-throw line 27 times, where they converted 22 free throws, an 81% success rate.

Blue Devils Team Defense

Louisville’s defense gave up 73 points, with the opposing team shooting 43% from the field, hitting 24 of their 55 attempts. Inside the arc, they connected on 18 of 33 shots, good for 54%.

From three-point range, the opposition made 6 of 22 attempts, shooting 27%. They also went to the free-throw line 27 times, making 22, an 81% success rate. Louisville allowed 9 offensive rebounds.

Cardinals vs Blue Devils Trends

  • Louisville has played well in their previous 5 road games, going 4-1 straight up. In this stretch, they averaged 78 points per game while allowing 65. The team also performed well vs the spread at 3-2.
  • When looking at their past five home matchups, Duke has an ATS record of 4-1 while averaging 88 per game. The team went 4-1 overall in these games.
  • Louisville has done well both straight up and vs the spread as the underdog, going 3-0 SU and 3-0 ATS in their last three games.
  • Although the Blue Devils have a strong straight up record in their last three games as the betting favorite, they have not done as well vs the spread going 1-2.

Cardinals vs Blue Devils Prediction

We’re putting our money on the Blue Devils to win, and have the projected score sitting at 77-69. We also like them to cover the spread, so our recommendation is to bet on the Blue Devils at -5.5.

Right now, the over/under line for the game is sitting at 145.5 and given that our model is projecting 146 points between the teams, we like the over.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.