Baltimore Orioles vs Boston Red Sox MLB Betting Prediction
PublishedMay 22, 2025,            Posted By: Maria Uebelhor
Last updated:May 22, 2025 ,

MLB Baltimore Orioles vs Boston Red Sox Prediction 5/22

The Baltimore Orioles will visit the Boston Red Sox at Fenway Park on Thursday, May 22, 2025. The game is set to start at 6:45 PM under the night sky. Fans can look forward to an exciting game between these two teams.

Orioles vs. Red Sox Betting Prediction

  • Money Line Prediction: Orioles MoneyLine: 108. The Orioles offer better betting value as underdogs. Their recent win against the Brewers shows potential, and the Red Sox have struggled at home recently.
  • Over/Under Prediction: Over 8.5 (-111). Both teams have shown strong hitting capabilities, and the starting pitchers have high ERAs, suggesting a higher-scoring game.

Team Trends

  • The Baltimore Orioles have a division record of 6-6 this season.
  • Boston Red Sox have a home record of 14-12 this season.
  • On May 21st, 2025, the Baltimore Orioles won against the Milwaukee Brewers with a score of 8-4.
  • Boston Red Sox defeated the New York Mets 2-0 on May 20th, 2025.
  • Rafael Devers hit a home run for the Boston Red Sox on May 20th, 2025, against the New York Mets.

Orioles vs Red Sox Preview

The Baltimore Orioles will take on the Boston Red Sox at Fenway Park on Thursday night. Cade Povich will start for the Orioles. He has pitched in 8 games this season with a record of 1-3. His ERA stands at 5.23, and he has struck out 38 batters over 41 1/3 innings.

For the Red Sox, Lucas Giolito will be on the mound. Giolito has made 4 starts this season, with a record of 1-1. His ERA is 7.08, and he has 17 strikeouts in 20 1/3 innings. Both teams will look to their pitchers to set the tone for the game. Fans can expect a competitive game under the lights at Fenway.

Boston Red Sox: Key Players and Team Performance

Rafael Devers is a top hitter for the Red Sox. He has played in 51 games this season. Devers ranks second in the league and team for home runs and runs, and first in RBIs. Alex Bregman has been a standout player as well. He leads the team and the league in home runs and runs. Bregman has a batting average of .297 and ranks second in RBIs for the team. Jarren Duran is another key player for the Red Sox. He has played 50 games and has a batting average of .265. Duran ranks third in runs and RBIs for the team.

Baltimore Orioles: Key Players and Team Performance

Cedric Mullins is a standout player for the Orioles. He has played in 46 games. Mullins leads the league and team in home runs, runs, and RBIs. Gunnar Henderson is another important player for Baltimore. He has participated in 41 games this season. Henderson ranks second on the team for home runs and shares the top spot in runs. Ryan O’Hearn has also contributed to the Orioles’ lineup. He has a batting average of .306 over 39 games. O’Hearn ranks second in home runs and runs for the team.

Final Betting Pick

The Orioles present a solid option for the money line bet. Despite their overall record, they have shown signs of improvement, especially with their recent win against the Brewers. The Red Sox have been inconsistent at home, which could give the Orioles an edge as underdogs.

For the over/under prediction, taking the over at 8.5 runs seems reasonable. Both teams have strong hitters, with players like Cedric Mullins and Rafael Devers leading their respective lineups. Additionally, both starting pitchers have high ERAs, suggesting that runs could come easily in this game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.