Baltimore Orioles vs Chicago White Sox MLB Betting Prediction
PublishedSeptember 15, 2025,            Posted By: Maria Uebelhor
Last updated:September 15, 2025 ,

MLB Baltimore Orioles vs Chicago White Sox Prediction 9/15

The Baltimore Orioles will take on the Chicago White Sox on Monday, September 15, 2025, at 7:40 PM. The game will be held at Rate Field in Chicago, IL. Fans can expect a warm evening with clear skies and a light breeze. Both teams are looking to break their current three-game losing streaks.

Orioles vs. White Sox Betting Prediction

  • Money Line Prediction: Baltimore Orioles -150. The Orioles have a better record than the White Sox and are 6-4 in their last 10 games. Despite being on a losing streak, they have shown more consistency than the White Sox, who have struggled at home with a 32-43 record.
  • Over/Under Prediction: Under 8.0 (-105). Both teams have been struggling to score in recent games, and with Kyle Bradish’s strong pitching stats for the Orioles, this game might see fewer runs.

Team Trends

  • The Baltimore Orioles have a road record of 33-42 this season.
  • The Chicago White Sox have a home record of 32-43 this season.
  • Both the Orioles and White Sox are on a 3-game losing streak.
  • The Orioles’ last win was on September 11th, 2025, against the Pittsburgh Pirates with a score of 3-2.
  • The White Sox’s last win was on September 11th, 2025, against the Tampa Bay Rays with a score of 5-1.

Orioles vs White Sox Preview

The Baltimore Orioles head to Chicago to take on the White Sox at Rate Field. Both teams are eager to end their three-game losing streaks. The Orioles have a record of 69-80 and are ranked fifth in their division. Meanwhile, the White Sox hold a 57-93 record, also sitting at the bottom of their division. The game starts at 7:40 PM and will be broadcast on CHSN.

On the mound for the Orioles is Kyle Bradish. He has an ERA of 2.65 and a WHIP of 0.94. Sean Burke will start for the White Sox. His ERA stands at 4.35 with a WHIP of 1.47. Fans can expect a warm evening with clear skies and a light breeze, perfect for baseball.

Chicago White Sox: Key Players and Stats

The Chicago White Sox have some strong hitters this season. Lenyn Sosa leads the team in home runs with 20 and has a batting average of .262. Miguel Vargas has played 127 games, leading the team in runs with 71. Chase Meidroth has a batting average of .269, showing consistency at the plate. Edgar Quero has a .282 batting average and has driven in 36 runs. Colson Montgomery, despite fewer games, has hit 18 home runs. The White Sox’s team batting average stands at .234, ranking 16th. Their on-base percentage is .302, while their slugging percentage is .375. They have hit 151 home runs this season, placing them 19th in the league.

Baltimore Orioles: A Look at the Lineup

The Baltimore Orioles have solid hitters in their lineup. Gunnar Henderson leads the team with 81 runs and a batting average of .271. Jackson Holliday follows closely with 68 runs and 17 home runs. Jordan Westburg, with a .276 batting average, adds depth to the team. Adley Rutschman and Ryan Mountcastle contribute to the Orioles’ offense. Rutschman has 37 runs in 85 games, while Mountcastle has played 81 games with 31 runs. Coby Mayo has also added 9 home runs in his 72 games. The Orioles’ team batting average is .239, ranking 13th in the league. Their on-base percentage is .306, and their slugging percentage is .399. With 176 home runs, they rank 12th in the league.

Final Betting Pick

The Baltimore Orioles are favored to win at -150. They have a better overall record compared to the Chicago White Sox. On the road, the Orioles have struggled, but the White Sox have been worse at home with a 32-43 record. The Orioles have also won two of their last five games, showing they can still compete even when not at their best.

The prediction for the game is under 8.0 runs. Both teams have had trouble scoring recently, and the Orioles’ starting pitcher, Kyle Bradish, has an ERA of 2.65. The White Sox’s starter, Sean Burke, has a higher ERA of 4.35, which might limit the Orioles’ scoring chances. With both teams’ recent struggles at the plate, a low-scoring game seems likely.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.