The Baltimore Orioles will play against the Cleveland Guardians on Monday, July 21, 2025. The game will take place at Progressive Field in Cleveland, OH, and is set to start at 6:40 PM. Fans can expect clear skies with a light breeze for this night game, which will be broadcast on MASN.

Orioles vs. Guardians Betting Prediction

• Money Line Prediction: Baltimore Orioles +115. The Orioles have shown some strength on the road recently, winning their last game against the Rays. With Sugano on the mound, they have a chance to continue their momentum.
• Over/Under Prediction: Over 8.5 (-103). Both teams have had high-scoring games recently, with the Guardians scoring 8 runs in their last win. The warm weather and wind blowing out could also favor hitters.

Team Trends

• The Baltimore Orioles have a road record of 22-29 this season.
• The Cleveland Guardians have a home record of 22-24 this season.
• Baltimore Orioles’ interim manager is Tony Mansolino.
• Cleveland Guardians’ manager is Stephen Vogt.
• The weather forecast for the game is a clear sky with a light breeze.

Orioles vs Guardians Preview

The Baltimore Orioles head to Progressive Field to take on the Cleveland Guardians. The game is set for Monday, July 21, 2025, with a start time of 6:40 PM. The Orioles will rely on Tomoyuki Sugano, who has a 4.44 ERA and a 1.30 WHIP. Sugano’s record stands at 7 wins and 5 losses, and he aims to add another win to his season.

On the other side, the Guardians have Tanner Bibee on the mound. Bibee has a 4.29 ERA and a WHIP of 1.24. His current record is 5 wins and 9 losses. The game will be under clear skies, and fans can catch the action on MASN. Both teams are ready to give it their all in this night game.

Guardians’ Key Players and Stats

The Cleveland Guardians have a standout player in José Ramírez. He has played 95 games with a batting average of .295. Ramírez leads the team with 19 home runs, ranking 13th in the league. Carlos Santana is another important player for the Guardians. He has a batting average of .228 and has hit 11 home runs this season. Santana’s 43 runs put him second on the team. Tanner Bibee will be the starting pitcher for the Guardians. His ERA is 4.29, and he has a WHIP of 1.24. Bibee has a record of 5 wins and 9 losses this season.

Orioles’ Key Players and Pitching Insights

Gunnar Henderson is a strong player for the Orioles. He has played 91 games and has a batting average of .280. Henderson leads the team with 50 runs, ranking first for the Orioles. Jackson Holliday is another player to watch. He has a batting average of .258 and has hit 13 home runs. Holliday’s 42 runs place him second on the team. The Orioles’ starting pitcher is Tomoyuki Sugano. His ERA is 4.44, and he has a WHIP of 1.30. Sugano has a record of 7 wins and 5 losses this season.

Final Betting Pick

The Orioles have a decent chance on the road. They recently defeated the Rays 5-3, showing they can perform well away from home. With Tomoyuki Sugano on the mound, who has a 7-5 record, they have a solid opportunity to continue their success. The Orioles’ recent road win and Sugano’s performance make the money line of +115 a reasonable pick.

Both teams have been involved in high-scoring games. The Guardians scored 8 runs in their last victory, and the Orioles also have players like Gunnar Henderson and Jackson Holliday who can contribute to the scoreboard. The weather conditions, with warm temperatures and wind blowing out, could further aid hitters. This makes the over 8.5 (-103) a sensible prediction for this game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.