Baltimore Orioles vs Cleveland Guardians MLB Betting Prediction
PublishedJuly 23, 2025,            Posted By: Maria Uebelhor
Last updated:July 23, 2025 ,

MLB Baltimore Orioles vs Cleveland Guardians Prediction 7/23

The Baltimore Orioles are set to play against the Cleveland Guardians on Wednesday, July 23, 2025. The game will take place at Progressive Field in Cleveland, OH, starting at 6:40 PM. Fans can expect a warm evening under broken clouds as they tune in on the CLEG channel to watch this night game.

Orioles vs. Guardians Betting Prediction

  • Money Line Prediction: Cleveland Guardians -129. The Guardians have a balanced home record of 24-24 and have won their last two games against the Orioles. With Slade Cecconi’s solid pitching stats, they are the safer pick.
  • Over/Under Prediction: Over 8.5 (-112). Recent games between these teams have seen high scores, with the last two games totaling 9 and 15 runs. Zach Eflin’s high ERA suggests more runs could be scored.

Team Trends

  • The Cleveland Guardians have a balanced home record of 24-24 this season.
  • Baltimore Orioles have a road record of 22-31 this season.
  • The Cleveland Guardians won their last game against the Baltimore Orioles 6-3.
  • José Ramírez hit a home run in the recent game against the Orioles.
  • The Orioles’ interim manager is Tony Mansolino.

Orioles vs Guardians Preview

The Baltimore Orioles will visit Progressive Field to play against the Cleveland Guardians on Wednesday evening. The Orioles will rely on Zach Eflin to lead them on the mound. Eflin has a 5.95 ERA and a WHIP of 1.44, with a record of 6 wins and 5 losses. The Orioles hope he can deliver a strong performance under the broken clouds forecasted for the night.

On the other side, the Cleveland Guardians will start Slade Cecconi. Cecconi has a 3.84 ERA and a WHIP of 1.23, with 5 wins and 4 losses this season. The Guardians look to use Cecconi’s skills to secure a win at home. Fans can watch the game on the CLEG channel, starting at 6:40 PM.

Cleveland Guardians: Key Players and Stats

José Ramírez is a standout for the Cleveland Guardians. He has played 97 games with a batting average of .295. Ramírez leads the team in home runs with 21 and has scored 61 runs. Carlos Santana is another important player for the Guardians. In 94 games, he has a batting average of .228. Santana has hit 11 home runs and has 43 runs batted in. Slade Cecconi is the starting pitcher for the Guardians. His ERA is 3.84 with a WHIP of 1.23. Cecconi has a win-loss record of 5-4 this season.

Baltimore Orioles: Key Players and Stats

Gunnar Henderson plays shortstop for the Orioles. He has a batting average of .278 in 93 games. Henderson has hit 11 home runs and leads the team with 51 runs. Jackson Holliday is another key player. As a second baseman, he has a batting average of .260. Holliday has 13 home runs and 40 runs batted in. Zach Eflin is the starting pitcher for the Orioles. His ERA is 5.95, and he has a WHIP of 1.44. Eflin’s win-loss record stands at 6-5 this season.

Final Betting Pick

The Cleveland Guardians look like a solid pick for the money line at -129. They have a home record of 24-24, showing they can hold their own at Progressive Field. Slade Cecconi’s pitching stats, with an ERA of 3.84 and WHIP of 1.23, add confidence to this choice. The Guardians have also won their last two games against the Orioles, which strengthens their position.

For the over/under prediction, the over 8.5 runs seems likely. Recent games between these teams have been high-scoring, with totals of 9 and 15 runs. Zach Eflin’s ERA of 5.95 suggests that more runs could be scored in this game. The Guardians’ recent offensive performance, scoring 10 and 6 runs in their last two games against the Orioles, supports this prediction.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.