St. Louis Cardinals vs Cleveland Guardians MLB Betting Prediction
PublishedJune 27, 2025,            Posted By: Maria Uebelhor
Last updated:June 27, 2025 ,

MLB Cardinals vs Cleveland Guardians Prediction 6/27

The St. Louis Cardinals will play against the Cleveland Guardians on Friday, June 27, 2025. The game will take place at Progressive Field in Cleveland, OH, starting at 7:10 PM. Fans can watch the game on APLTV, with a weather forecast of light rain and a light breeze.

Cardinals vs. Guardians Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine at -125. The Cardinals have a slightly better overall record and a strong starting pitcher in Sonny Gray. Their road record is not great, but they have shown they can win away games.
  • Over/Under Prediction: Under 8.5. Both teams have shown struggles in scoring recently, with the Cardinals failing to score in two of their last three games and the Guardians being shut out in their last game.

Team Trends

  • The St. Louis Cardinals have an overall season record of 44-38.
  • The Cleveland Guardians hold a home record of 20-17 this season.
  • The Cardinals have struggled on the road with a record of 18-21.
  • The Guardians recently lost 0-6 against the Toronto Blue Jays at home.
  • The game is scheduled to start at 7:10 PM at Progressive Field in Cleveland.

Cardinals vs Guardians Preview

The St. Louis Cardinals will take on the Cleveland Guardians at Progressive Field. This game is set for Friday, June 27, 2025, at 7:10 PM. The Cardinals aim to capitalize on their strong season with Sonny Gray on the mound. Gray has a solid record, with a 7-2 win-loss and an ERA of 3.72. His consistency can be a key factor for the Cardinals.

The Guardians will counter with Luis L. Ortiz as their starting pitcher. Ortiz has a 4-8 win-loss record and an ERA of 4.30. The Guardians will look to improve their standing with a win at home. Fans can catch the game on APLTV, and the weather forecast predicts light rain with a light breeze. Both teams will need to adjust to the weather as they play under the lights.

Guardians Gear Up for the Game

The Cleveland Guardians have some standout hitters this season. José Ramírez leads the team with a batting average of .317. He also tops the team in home runs with 13 and RBIs with 38. Carlos Santana is another key player for the Guardians. He has played 74 games with a batting average of .234. Santana has 9 home runs and 37 RBIs, ranking second on the team in both categories. Luis L. Ortiz will start as the pitcher for the Guardians. He has a record of 4 wins and 8 losses. Ortiz’s ERA stands at 4.30, and his WHIP is 1.41.

Cardinals Ready to Compete

The St. Louis Cardinals have some strong hitters this season. Willson Contreras leads the team with 10 home runs and 50 RBIs. Brendan Donovan is another key player, with a batting average of .301 and 43 runs. Nolan Arenado is a reliable player for the Cardinals. He has 10 home runs and 39 RBIs. Masyn Winn contributes with a batting average of .257 and 49 runs. Sonny Gray will start as the pitcher for the Cardinals. He has a record of 7 wins and 2 losses. Gray’s ERA is 3.72, and his WHIP is 1.19.

Final Betting Pick

The Cardinals are favored on the money line at -125. This is a solid pick because they have a better overall record and a strong starting pitcher in Sonny Gray. Gray’s ERA of 3.72 and WHIP of 1.19 show he can limit runs and base runners effectively.

For the over/under, the prediction is under 8.5. Both teams have had trouble scoring recently, with the Cardinals not scoring in two of their last three games. The Guardians were also shut out in their last game, which supports the under pick.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.