St. Louis Cardinals vs Cleveland Guardians MLB Betting Prediction
PublishedJune 28, 2025,            Posted By: Maria Uebelhor
Last updated:June 28, 2025 ,

MLB Cardinals vs Cleveland Guardians Prediction 6/28

The St. Louis Cardinals will take on the Cleveland Guardians on Saturday, June 28, 2025. The game will be held at Progressive Field in Cleveland, OH, and is scheduled to start at 4:10 PM. Expect a warm afternoon with light rain and a crosswind as these teams meet on the field.

Cardinals vs. Guardians Betting Prediction

  • Money Line Prediction: Cardinals +104. The Cardinals have a better overall record and recently defeated the Guardians 5-0. Their road record is close to even, making them a good value bet as underdogs.
  • Over/Under Prediction: Under 8.5. Recent games for both teams have been low-scoring, with the Cardinals winning 5-0 and the Guardians losing 0-6. The weather forecast of light rain might also affect scoring.

Team Trends

  • The St. Louis Cardinals have a road record of 19-21 this season.
  • The Cleveland Guardians hold a home record of 20-18 this season.
  • In their last game against the Guardians, the Cardinals won 5-0 with Sonny Gray pitching a complete game.
  • During their last home series, the Guardians faced the Toronto Blue Jays, winning one out of three games.
  • The Cardinals are 3 games behind the leader in the NL Central division.

Cardinals vs Guardians Preview

The St. Louis Cardinals are set to play against the Cleveland Guardians at Progressive Field. This game is scheduled for Saturday, June 28, 2025, at 4:10 PM. The weather forecast predicts a warm afternoon with light rain and a crosswind, which might affect gameplay.

Miles Mikolas will start for the Cardinals. He has an ERA of 4.31 and a WHIP of 1.28, with a record of 4 wins and 5 losses. On the other side, Slade Cecconi will pitch for the Guardians. Cecconi has an ERA of 3.38, a WHIP of 1.29, and a record of 3 wins and 3 losses. Both pitchers will aim to lead their teams to victory in this afternoon game.

Cleveland Guardians: Key Players and Stats

José Ramírez is a standout for the Cleveland Guardians. He has played 77 games with a batting average of .317. Ramírez leads the team in home runs with 13 and has 43 runs.

Carlos Santana has also been important for the Guardians. He has a batting average of .234 over 74 games. Santana has hit 9 home runs and scored 36 runs.

The Guardians’ starting pitcher, Slade Cecconi, has an ERA of 3.38. His WHIP is 1.29, and his record is 3-3. Cecconi’s performance will be crucial for the Guardians in this game.

St. Louis Cardinals: Key Contributors and Performance

Willson Contreras is a top player for the Cardinals. He has played 78 games with a batting average of .246. Contreras leads the team in home runs with 10 and has 50 RBIs. Brendan Donovan is another important player. He has a batting average of .300 in 75 games. Donovan has scored 43 runs and has 29 RBIs. The Cardinals’ starting pitcher, Miles Mikolas, has an ERA of 4.31. His WHIP is 1.28, and his record is 4-5. Mikolas will be a key player to watch in this game.

Final Betting Pick

The Cardinals are a solid pick for the money line at +104. They have a slightly better record than the Guardians at 45-38. The Cardinals also recently won 5-0 against the Guardians, showing their ability to perform well on the road. With a road record of 19-21, they are close to even, making them a good value bet as underdogs.

For the over/under prediction, going with under 8.5 seems wise. Both teams have been in low-scoring games recently. The Cardinals had a 5-0 win, and the Guardians had a 0-6 loss. The weather forecast of light rain might also keep scoring low, affecting how the game plays out. Both teams have pitchers with ERAs under 4.5, which might limit runs scored.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.