St. Louis Cardinals vs Cleveland Guardians MLB Betting Prediction

MLB Cardinals vs Cleveland Guardians Prediction 6/29

The St. Louis Cardinals will take on the Cleveland Guardians on Sunday, June 29, 2025. The game is set for 12:05 PM at Progressive Field in Cleveland, OH. Fans can expect clear skies and mild weather for this afternoon game, which will be broadcast on Roku.

Cardinals vs. Guardians Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine at -121. The Cardinals have won the last two games against the Guardians and have a slightly better road record. The Guardians have struggled at home recently.
  • Over/Under Prediction: Over 8.5. Both teams have shown the ability to score runs, with the Cardinals winning 9-6 in their last game. The starting pitchers have ERAs above 3.90, which could lead to more runs.

Team Trends

  • The St. Louis Cardinals have a road record of 20-21 this season.
  • The Cleveland Guardians hold a home record of 20-19 this season.
  • In their last game on June 28, 2025, the Cardinals defeated the Guardians 9-6.
  • Sonny Gray of the Cardinals pitched a complete game shutout against the Guardians on June 27, 2025.
  • The Guardians have lost their last three games at home, including two against the Cardinals.

Cardinals vs Guardians Preview

The St. Louis Cardinals will head to Progressive Field to play against the Cleveland Guardians on Sunday, June 29, 2025. The game is scheduled for an afternoon start at 12:05 PM. Fans can enjoy the game under clear skies with mild weather, making it a pleasant day for baseball.

Matthew Liberatore will take the mound for the Cardinals. He has a 3.96 ERA and a WHIP of 1.15. The Guardians will counter with Logan Allen, who has a 4.25 ERA and a WHIP of 1.50. Both pitchers have similar records this season, with Liberatore at 5-6 and Allen at 5-5. This matchup could be a close one, as both teams look to gain an edge.

Cleveland Guardians: Key Players and Performance Insights

The Cleveland Guardians have some standout hitters this season. José Ramírez leads the team with a .312 batting average. He also has 13 home runs and 38 RBIs, ranking first on the team in these categories. Carlos Santana is another key player for the Guardians. He has played 75 games and has a batting average of .231. Santana has hit 9 home runs and has 37 RBIs, placing him second on the team in both stats. Logan Allen is set to start as the pitcher for the Guardians. His ERA is 4.25, and his win-loss record stands at 5-5. The team hopes for a strong performance from him in the upcoming game.

St. Louis Cardinals: Key Players and Insights

Willson Contreras is leading the Cardinals with 11 home runs. He has a batting average of .249 and has played 79 games. Contreras also leads the team with 51 RBIs. Brendan Donovan is another important player for the Cardinals. He has a batting average of .302 and has played in 76 games. Donovan has 6 home runs and 31 RBIs. Matthew Liberatore will start as the pitcher for the Cardinals. His ERA is 3.96, and he has a win-loss record of 5-6. The team looks to him for a solid performance in the game.

Final Betting Pick

The Cardinals are a solid pick for the MoneyLine at -121. They have a slightly better road record at 20-21 compared to the Guardians’ home record of 20-19. The Cardinals have also won the last two games against the Guardians, showing they can perform well away from home.

The Over 8.5 prediction is supported by both teams’ recent scoring ability. In their last game, the Cardinals won 9-6, indicating a high-scoring trend. With starting pitchers Matthew Liberatore and Logan Allen having ERAs above 3.90, more runs could be expected in this game.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.