Chicago Cubs vs Pittsburgh Pirates MLB Betting Prediction
PublishedSeptember 15, 2025,            Posted By: Maria Uebelhor
Last updated:September 15, 2025 ,

MLB Chicago Cubs vs Pittsburgh Pirates Prediction 9/15

On Monday, September 15, 2025, the Chicago Cubs will take on the Pittsburgh Pirates at PNC Park in Pittsburgh, PA. The Cubs hold a record of 85-64 and are ranked 2nd in their division, while the Pirates are 65-85 and ranked 5th. The game is set for 6:40 PM and will be broadcasted on SN PT, with a weather forecast of a warm day and scattered clouds.

Cubs vs. Pirates Betting Prediction

  • Money Line Prediction: Chicago Cubs -132. The Cubs have a better overall record and a decent road record. The Pirates have struggled recently, going 2-8 in their last 10 games.
  • Over/Under Prediction: Under 8.0 (-103). Both teams have starting pitchers with solid ERAs, and the Pirates’ offense ranks low in slugging percentage, which could lead to a lower-scoring game.

Team Trends

  • The Chicago Cubs have a road record of 39-35 this season.
  • The Pittsburgh Pirates have a home record of 42-33 this season.
  • The Cubs recently won a close game against the Tampa Bay Rays with a score of 4-3.
  • The Pirates lost their last game against the Washington Nationals with a score of 4-3.
  • The game will be played at PNC Park in Pittsburgh with a forecast of scattered clouds and a light breeze.

Cubs vs Pirates Preview

On Monday evening, the Chicago Cubs will travel to PNC Park to play the Pittsburgh Pirates. The Cubs have a record of 85-64 and are in second place in their division. They have won five of their last ten games. The Pirates, with a record of 65-85, are in fifth place and have won just two of their last ten games.

Jameson Taillon will start for the Cubs. He has a 4.15 ERA and a 9-6 record. For the Pirates, Braxton Ashcraft will take the mound. He holds a 2.47 ERA and a 4-2 record. The weather is expected to be warm with scattered clouds, creating a pleasant evening for baseball.

Pittsburgh Pirates: Key Players and Stats

The Pittsburgh Pirates are relying on Andrew McCutchen this season. McCutchen has played in 126 games with a batting average of .241. He leads the team in home runs with 13 and has scored 48 runs. Spencer Horwitz is another important player for the Pirates. He has a batting average of .260 over 97 games. Horwitz ranks second on the team with 47 runs and 42 RBIs. Jared Triolo adds to the Pirates’ lineup with his performance at shortstop. He has played in 96 games with a batting average of .230. Triolo has hit 6 home runs and scored 37 runs this season.

Chicago Cubs: Key Players and Stats

Seiya Suzuki is a standout player for the Chicago Cubs. He has played in 140 games with a batting average of .244. Suzuki leads the team with 27 home runs and 91 RBIs. Dansby Swanson plays shortstop for the Cubs. He has appeared in 146 games and has a batting average of .246. Swanson is second on the team with 22 home runs and has scored 80 runs. Nico Hoerner plays second base and has a batting average of .299. He has played in 143 games and has scored 77 runs. Hoerner also has 59 RBIs this season.

Final Betting Pick

The Cubs are a strong pick for the money line at -132. They have a solid overall record of 85-64 and a decent road record of 39-35. The Pirates have been struggling, with a 2-8 record in their last 10 games, which makes the Cubs a safer bet.

For the over/under prediction, going under 8.0 (-103) seems wise. Both starting pitchers have good ERAs, with Taillon at 4.15 and Ashcraft at 2.47. The Pirates’ offense ranks low in slugging percentage, which suggests a lower-scoring game is likely.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.