Chicago Cubs vs Pittsburgh Pirates MLB Betting Prediction
PublishedSeptember 16, 2025,            Posted By: Maria Uebelhor
Last updated:September 16, 2025 ,

MLB Chicago Cubs vs Pittsburgh Pirates Prediction 9/16

The Chicago Cubs will take on the Pittsburgh Pirates on Tuesday, September 16, 2025, at 6:40 PM. The game will be held at PNC Park in Pittsburgh, PA. The weather is expected to be warm with scattered clouds. The Cubs have a record of 86-64 and are on a two-game winning streak, while the Pirates have a record of 65-86 and have lost their last two games.

Cubs vs. Pirates Betting Prediction

  • Money Line Prediction: Chicago Cubs +107. The Cubs have a better recent record and are on a two-game winning streak. The Pirates have lost their last two games and have struggled in their last ten games.
  • Over/Under Prediction: Under 7.0 (-116). Both starting pitchers have low ERAs, and the previous game between these teams ended with a total of four runs.

Team Trends

  • The Chicago Cubs have a road record of 40-35 this season.
  • The Pittsburgh Pirates hold a home record of 42-34 this season.
  • In their last game, the Chicago Cubs won against the Pittsburgh Pirates with a score of 4-0.
  • The Pittsburgh Pirates have struggled recently, going 1-9 in their last 10 games.
  • The Chicago Cubs are currently on a 2-game winning streak.

Cubs vs Pirates Preview

The Chicago Cubs are set to meet the Pittsburgh Pirates at PNC Park. The Cubs are in second place in their division and have won six of their last ten games. They aim to extend their two-game winning streak. The Pirates, sitting in fifth place, have struggled recently, winning only one of their last ten games.

On the mound for the Cubs is Cade Horton, who has an ERA of 2.70 and a WHIP of 1.11. Horton has a strong record of 10 wins and 4 losses. The Pirates will counter with Paul Skenes, who boasts an ERA of 1.92 and a WHIP of 0.92. Skenes has 10 wins and 9 losses this season. Fans can expect a competitive game with these two pitchers leading their teams.

Pirates’ Key Players and Season Overview

Andrew McCutchen leads the Pirates in home runs, runs, and RBIs. He has played 127 games with a batting average of .239. His on-base percentage is .334, and his slugging percentage is .376. Spencer Horwitz has a batting average of .260 over 98 games. He ranks second on the team in home runs and runs. His on-base percentage is .336, and his slugging percentage is .406. Paul Skenes is the starting pitcher for the Pirates. His ERA is 1.92, and his WHIP is 0.92. He has a win-loss record of 10-9 this season.

Cubs’ Stars Ready for Action

Seiya Suzuki is a key player for the Cubs. He has played 140 games with a batting average of .244. Suzuki has 27 home runs and 91 RBIs, leading the team in RBIs. Dansby Swanson is another important hitter for the Cubs. He has a batting average of .248 over 147 games. Swanson has 22 home runs and 80 runs, leading the team in runs. Cade Horton will be the starting pitcher for the Cubs. His ERA is 2.70, and his WHIP is 1.11. Horton has a win-loss record of 10-4 this season.

Final Betting Pick

The Cubs are a solid pick for the money line at +107. They have won their last two games, including a 4-0 victory over the Pirates. Their recent road record of 40-35 shows they can perform well away from home. The Pirates, on the other hand, have lost their last two games and have struggled with a division record of 17-30.

The under 7.0 total is a smart choice due to the starting pitchers’ low ERAs. Cade Horton of the Cubs has an ERA of 2.70, while Paul Skenes of the Pirates has an ERA of 1.92. In their last game, these teams combined for only four runs, highlighting the effectiveness of both pitchers and supporting the under prediction.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.