Chicago White Sox vs Boston Red Sox MLB Betting Prediction
PublishedApril 21, 2025,            Posted By: Maria Uebelhor
Last updated:April 21, 2025 ,

MLB Chicago White Sox vs Boston Red Sox Prediction 4/21

The Chicago White Sox will visit Fenway Park to take on the Boston Red Sox on Monday, April 21, 2025. The game is set to begin at 11:10 AM. Fans can look forward to an exciting evening of baseball action.

White Sox vs. Red Sox Betting Prediction

  • Money Line Prediction: White Sox MoneyLine: 239. The White Sox offer a high reward for a win. They recently beat the Red Sox 8-4, showing potential despite their overall record.
  • Over/Under Prediction: Under 9.0 (-118). Both teams have pitchers with ERAs over 4, but their recent games have not consistently reached high scores. The White Sox’s batting average is also low, which might keep the total under.

Team Trends

  • The Chicago White Sox have a record of 5-16 this season, with only 1 win on the road.
  • Boston Red Sox have a 12-11 record this season and are 2 games back in the AL East.
  • In a recent game against the Boston Red Sox, Chicago White Sox won 8-4 with 9 hits and 2 home runs.
  • Boston Red Sox pitcher Tanner Houck struck out 7 batters in a recent game against the White Sox.
  • In a game against the Tampa Bay Rays, Boston Red Sox’s Alex Bregman hit 2 home runs and had 4 RBIs.

White Sox vs Red Sox Preview

The Chicago White Sox will meet the Boston Red Sox at Fenway Park for a night game on Monday, April 21, 2025. The game is set to begin at 11:10 AM. Fans can expect an interesting matchup as both teams bring their strengths to the field.

Jonathan Cannon will start for the White Sox. He has shown mixed results this season with a 4.42 ERA over 18 1/3 innings. Walker Buehler will take the mound for the Red Sox. His season ERA stands at 5.23 across 20 2/3 innings. Both pitchers aim to control the game from the start.

Boston Red Sox: Key Players and Performance Insights

The Boston Red Sox have some strong hitters this season. Trevor Story is leading the team in home runs with 5 and has a batting average of .318. Wilyer Abreu is also contributing with 4 home runs and a .286 batting average. Alex Bregman is out due to personal reasons, but he has been a key player. Before his absence, he had a batting average of .292 and led the team with 16 RBIs. His presence on the field will be missed. On the pitching side, Walker Buehler has been solid in his recent games. He has a record of 2-1 with an ERA of 5.23 over 20 2/3 innings. Buehler will look to build on his performance against the White Sox.

Chicago White Sox: Key Players and Performance Insights

The Chicago White Sox have some players to watch this season. Luis Robert Jr. has played 19 games, hitting 2 home runs with a batting average of .154. He leads the team in runs with 10 and is third in RBIs with 6. Andrew Vaughn has played 20 games and leads the team with 3 home runs. He also has 10 RBIs, topping the team in that category. Vaughn’s batting average stands at .152. Miguel Vargas, playing 21 games, has 7 runs and 6 RBIs. His batting average is .147, and he has not hit any home runs this season. Jonathan Cannon is the starting pitcher for the White Sox in the upcoming game. He has a record of 0-2 with an ERA of 4.42 over 18 1/3 innings this season. In his recent game against the Athletics, he pitched 4 1/3 innings without allowing any runs. Cannon’s performance has been mixed, with some strong outings and others where he struggled. His best game was against the Angels, where he allowed no runs over 5 innings. The White Sox team stats show some areas for improvement. Their batting average is .198, which ranks 25th in the league. The team has hit 16 home runs and has 16 stolen bases, ranking 16th and 10th, respectively. On the pitching side, their ERA is 4.34, placing them 23rd. The team has allowed 27 home runs, ranking 13th in the league.

Final Betting Pick

The White Sox MoneyLine at 239 offers a high reward for bettors. Despite their poor record, the White Sox recently showed they can win against the Red Sox, taking a game 8-4. Jonathan Cannon’s recent performance against the Athletics, where he allowed no runs, adds confidence to this pick.

For the Over/Under prediction, taking the Under 9.0 (-118) seems wise. Both teams have pitchers with ERAs over 4, but recent games have not seen high scores. The White Sox’s low batting average and the absence of Alex Bregman for the Red Sox could keep the total score low.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.