Chicago White Sox vs Chicago Cubs MLB Betting Prediction
PublishedMay 16, 2025,            Posted By: Maria Uebelhor
Last updated:May 16, 2025 ,

MLB Chicago White Sox vs Chicago Cubs Prediction 5/16

On Friday, May 16, 2025, the Chicago White Sox will take on the Chicago Cubs at Wrigley Field. The game is set to start at 2:20 PM. Fans can look forward to an exciting night game between these two teams.

White Sox vs. Cubs Betting Prediction

  • Money Line Prediction: Chicago Cubs MoneyLine: -224. The Cubs have a stronger record and better hitting stats. Their home performance is solid, making them a safer choice.
  • Over/Under Prediction: Under 11.5 (-114). Both teams have similar ERA rankings, and the White Sox have struggled offensively, suggesting a lower-scoring game.

Team Trends

  • The Chicago White Sox have a regular season record of 14-30 and are 15 games back in the AL Central.
  • The Chicago Cubs have a regular season record of 25-19, with a home record of 12-10.
  • In their recent game against the Cincinnati Reds, Bryse Wilson of the White Sox allowed 10 hits and 7 earned runs over 5 1/3 innings.
  • In the Cubs’ recent game against the Miami Marlins, Jameson Taillon pitched 6 innings with 7 strikeouts but allowed 3 home runs.
  • Lenyn Sosa of the White Sox hit a home run in their win against the Cincinnati Reds on May 14th, 2025.

White Sox vs Cubs Preview

On May 16, 2025, the Chicago White Sox will visit the Chicago Cubs at Wrigley Field. The game starts at 2:20 PM and will be under the lights. Fans can expect an interesting matchup between these two city rivals.

Shane Smith will start on the mound for the White Sox. He has a 2.08 ERA over 43 1/3 innings this season. For the Cubs, Cade Horton will take the ball. Horton has pitched only four innings this season, holding a 6.75 ERA. Both pitchers will aim to control the game early for their teams.

Chicago Cubs: Key Players and Season Insights

The Chicago Cubs have some strong hitters in their lineup. Kyle Tucker plays right field and has a batting average of .263. He also has 10 home runs and leads the league in runs with 33. Pete Crow-Armstrong is another key player with a batting average of .266 and 11 home runs. He ranks first in the league for home runs and second for runs with 32. Seiya Suzuki, the designated hitter, has a batting average of .239 and leads the team with 35 RBIs. He also has 11 home runs, tying him with Crow-Armstrong for the team lead. Cade Horton is a starting pitcher for the Cubs. He has played one game this season with an ERA of 6.75. His WHIP stands at 1.00, and he has struck out five batters. During spring training, Horton pitched in two games with an ERA of 3.00. He recorded one save and struck out two batters. His K/9 rate was 6.00 in spring training. The Cubs’ team stats show strengths and weaknesses. Their batting average is .250, ranking 12th. They have a slugging percentage of .436, which ranks third. The Cubs have hit 63 home runs, also ranking third. On the pitching side, their ERA is 4.04, ranking 18th. They have allowed 52 home runs, ranking 16th.

Chicago White Sox: Player Highlights and Team Overview

Luis Robert Jr. is a key player for the Chicago White Sox. He has a batting average of .186 with five home runs. Robert Jr. is day-to-day with knee soreness but is expected to play soon. Miguel Vargas plays third base for the White Sox. His batting average is .221, and he has three home runs. Vargas is dealing with a calf injury but should be ready to play. Shane Smith is a starting pitcher for the White Sox. He has started eight games with an ERA of 2.08. Smith has struck out 38 batters and has a WHIP of 1.08.

Final Betting Pick

The Cubs are a strong pick for the Money Line due to their better overall record and hitting stats. They have a .250 team batting average, which ranks 12th, and they are 3rd in slugging percentage. Their home record of 12-10 shows they play well at home, adding confidence to their Money Line odds of -224.

The Under 11.5 bet looks favorable given the pitching and hitting stats. Both teams have similar ERA rankings, with the White Sox at 4.04 and the Cubs at 4.04 as well. The White Sox’s struggles with a .214 batting average and low slugging percentage suggest a lower-scoring game. These factors make the Under 11.5 a reasonable choice.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.