Chicago White Sox vs Chicago Cubs MLB Betting Prediction
PublishedMay 17, 2025,            Posted By: Maria Uebelhor
Last updated:May 17, 2025 ,

MLB Chicago White Sox vs Chicago Cubs Prediction 5/17

On Saturday, May 17, 2025, the Chicago White Sox will take on the Chicago Cubs at Wrigley Field. The game is set to start at 2:20 PM. Fans can look forward to an evening of baseball under the lights.

White Sox vs. Cubs Betting Prediction

  • Money Line Prediction: Cubs MoneyLine: -282. The Cubs have a better record and stronger hitting stats. They also have a solid starting pitcher in Matthew Boyd, who has a lower ERA than Sean Burke.
  • Over/Under Prediction: Under 10.0 (-109). Both teams have average pitching stats, but the White Sox struggle with hitting, which could keep the total score lower.

Team Trends

  • The Chicago White Sox have a division record of 2-14 this season.
  • The Chicago Cubs have a road record of 13-9 this season.
  • In a recent game on May 16th, 2025, the Chicago Cubs defeated the Chicago White Sox 13-3.
  • Miguel Vargas from the Chicago White Sox hit 2 home runs in the game against the Cubs on May 16th, 2025.
  • Pete Crow-Armstrong of the Chicago Cubs had 6 RBIs in the game against the White Sox on May 16th, 2025.

White Sox vs Cubs Preview

On May 17, 2025, the Chicago White Sox will meet the Chicago Cubs at Wrigley Field. The game will start at 2:20 PM. The White Sox will have Sean Burke on the mound. Burke has a 2-4 record this season with an ERA of 4.15. He has pitched in 43 1/3 innings and struck out 29 batters.

The Cubs will counter with Matthew Boyd. Boyd has a 3-2 record and an ERA of 2.78. He has pitched 45 1/3 innings and struck out 45 batters. Fans can expect an interesting game as these two pitchers take the field. Both teams will look to gain an edge in this city rivalry.

Cubs’ Key Players and Season Overview

The Chicago Cubs have shown strong hitting in the 2025 season. Kyle Tucker has played 45 games with a batting average of .267. He leads the league in runs with 34 and is third in home runs and RBI on the team. Pete Crow-Armstrong is another standout for the Cubs. He has a batting average of .282 and leads the team with 12 home runs. His 36 RBI rank second in the league, highlighting his impact in 45 games. Seiya Suzuki has played 41 games and holds a .246 batting average. He has 11 home runs, ranking second on the team. Suzuki leads the league with 37 RBI, making him a key player for the Cubs.

White Sox Seek Redemption on the Road

The Chicago White Sox have had a challenging season. Luis Robert Jr. is a key player despite dealing with a knee issue. He has played 41 games and has 5 home runs and 17 RBI. Miguel Vargas has also been important for the White Sox. He has played 42 games and leads the team with 19 RBI. Vargas is managing a calf injury but is expected to play. Andrew Vaughn has been consistent at first base. He has 5 home runs and 18 RBI in 43 games. Vaughn’s batting average is .185, which the team hopes to improve.

Final Betting Pick

The Cubs have a strong case for the MoneyLine bet. Their record of 26-19 is much better than the White Sox’s 14-31. The Cubs’ batting stats are also better, with a .253 average and .440 slugging percentage, compared to the White Sox’s .217 average and .329 slugging percentage.

Matthew Boyd gives the Cubs an edge on the mound. Boyd’s ERA of 2.78 is lower than Sean Burke’s 4.15. This pitching advantage, combined with the White Sox’s struggles at the plate, supports the Under 10.0 prediction. The Cubs’ solid pitching and the White Sox’s weak hitting could keep the total score low.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.