Chicago White Sox vs Chicago Cubs MLB Betting Prediction
PublishedMay 18, 2025,            Posted By: Maria Uebelhor
Last updated:May 18, 2025 ,

MLB Chicago White Sox vs Chicago Cubs Prediction 5/18

On Sunday, May 18, 2025, the Chicago White Sox will take on the Chicago Cubs at Wrigley Field. The game is set to start at 2:20 PM. Fans can expect an exciting night game between these two teams.

White Sox vs. Cubs Betting Prediction

  • Money Line Prediction: White Sox MoneyLine: +243. The White Sox are the underdog, but with a high payout, they offer value. They have struggled, but they can pull off an upset against the Cubs.
  • Over/Under Prediction: Over 8.0 (-106). Both teams have shown they can score runs, and the Cubs’ strong hitting could push the total over.

Team Trends

  • The Chicago White Sox have a division record of 2-14 this season.
  • The Chicago Cubs have a road record of 13-9 this season.
  • In a recent game against the Cubs, the White Sox hit two home runs but lost 7-3.
  • Chicago Cubs’ Matthew Boyd pitched 6 innings with 8 strikeouts in a win against the White Sox.
  • Pete Crow-Armstrong had 6 RBIs in a 13-3 win for the Cubs against the White Sox.

White Sox vs Cubs Preview

The Chicago White Sox will visit the Chicago Cubs at Wrigley Field on Sunday, May 18, 2025, with the game starting at 2:20 PM. The White Sox will have Jonathan Cannon on the mound. Cannon has pitched in nine games this season, starting seven of them. He holds a 2-4 record with a 3.60 ERA. His WHIP stands at 1.36, and he has struck out 39 batters in 50 innings.

The Cubs will rely on Colin Rea as their starting pitcher. Rea has appeared in nine games this season, starting six. He boasts a 3-0 record with a 2.48 ERA. His WHIP is 1.21, and he has 29 strikeouts in 36 1/3 innings. Fans can look forward to seeing how these pitchers perform against each other in this night game.

Cubs’ Key Players and Season Overview

The Chicago Cubs have some strong hitters this season. Kyle Tucker has played 46 games with a batting average of .264. He has hit 10 home runs and leads the team in runs with 34.

Pete Crow-Armstrong is another standout player. He has a batting average of .285 and leads the league with 12 home runs. Crow-Armstrong also tops the league with 38 RBIs.

Dansby Swanson is contributing well, too. His batting average is .253, and he has hit 10 home runs. Swanson ranks second on the team with 32 runs.

White Sox Seek to Improve Against Cubs

Luis Robert Jr. leads the Chicago White Sox in home runs and runs this season. He has played 42 games with a batting average of .176. Robert Jr. is dealing with knee soreness but is expected to play. Miguel Vargas plays third base for the White Sox. He has a batting average of .237 and leads the team with 20 RBIs. Vargas is also managing a calf injury but should be ready to take the field. Andrew Vaughn is another key player for the White Sox. He has hit 5 home runs and has 18 RBIs. Vaughn’s batting average is .186, and he has played in 44 games this season.

Final Betting Pick

The White Sox MoneyLine at +243 is a valuable pick despite their struggles this season. Their record shows they have had a tough time, but they have players like Luis Robert Jr. and Miguel Vargas who can make an impact. These hitters have shown they can produce runs, which could lead to an upset against the Cubs.

The Over 8.0 is also a solid choice given both teams’ ability to score. The Cubs have a strong lineup with players like Pete Crow-Armstrong and Kyle Tucker, who have been consistent at the plate. With both teams capable of putting up runs, the total could easily go over 8.0.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.