Chicago White Sox vs Minnesota Twins MLB Betting Prediction

MLB Chicago White Sox vs Minnesota Twins Prediction 4/22

The Chicago White Sox will take on the Minnesota Twins at Target Field on Tuesday, April 22, 2025. The game is set to start at 7:40 PM under the night sky. Fans are eager to see how these two teams perform in this matchup.

White Sox vs. Twins Betting Prediction

  • Money Line Prediction: White Sox MoneyLine: +207. The White Sox are the underdog, but the potential payout is higher. Despite their poor record, they have a chance with Davis Martin pitching, who has shown some solid outings.
  • Over/Under Prediction: Over 8.5 (-115). Both teams have struggled with pitching, and their recent games have seen higher scores. This suggests a likelihood of the total runs going over the set line.

Team Trends

  • The Chicago White Sox have a regular season record of 5-17 and are 8 games back in the AL Central.
  • The Minnesota Twins have a regular season record of 7-15 and are 6 games back in the AL Central.
  • In a recent game against the Boston Red Sox, Chicago’s Jonathan Cannon pitched 6 innings with 4 earned runs allowed.
  • During a game against the Atlanta Braves, Minnesota’s Joe Ryan allowed 3 home runs in 5 innings.
  • Byron Buxton of the Minnesota Twins had a home run and a double in a game against the Atlanta Braves.

White Sox vs Twins Preview

The Chicago White Sox and the Minnesota Twins are set to meet at Target Field. Davis Martin will start for the White Sox. Martin has pitched 22 1/3 innings this season with an ERA of 4.84. His recent game against the Athletics saw him allow four runs over 5 1/3 innings.

Bailey Ober will take the mound for the Twins. Ober has a 6.16 ERA over 19 innings this season. In his last outing against the Mets, he pitched 6 1/3 innings, allowing three runs. Both pitchers will look to improve their performances under the night sky.

Twins Take the Field: Key Players and Stats

The Minnesota Twins have some hitters to watch. Byron Buxton leads the team with 4 home runs and 17 runs. Harrison Bader is also contributing with a .250 batting average and 12 RBIs. Ty France has played in 22 games this season. He has a batting average of .234 and 2 home runs. His on-base percentage is .314, which is higher than Buxton’s. Bailey Ober will start for the Twins. He has a 1-1 record with a 6.16 ERA this season. In his last game, he pitched 6 1/3 innings against the Mets, allowing 3 earned runs.

White Sox Seek Victory: Key Players and Stats

The Chicago White Sox have had a rough start. Luis Robert Jr. has played in 20 games, but his batting average is .145. He has 2 home runs and leads the team with 10 runs. Andrew Benintendi is out with an injury. He played 14 games before his injury, with a batting average of .245. He had 4 home runs and 8 RBIs. Andrew Vaughn has 3 home runs and 10 RBIs. His batting average is .152. The team hopes he can improve his performance soon.

Final Betting Pick

The White Sox as underdogs present a valuable pick with a MoneyLine of +207. Despite their poor record, Davis Martin has had some solid outings, like his game against Boston where he allowed only one run over six innings. This shows he can perform well, giving the White Sox a fighting chance.

The Over 8.5 runs prediction is supported by both teams’ recent struggles in pitching. The White Sox have a 4.34 ERA, while the Twins have a 4.03 ERA. Both teams have allowed a significant number of home runs, which could lead to a high-scoring game.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.