Cincinnati Reds vs Pittsburgh Pirates MLB Betting Prediction
PublishedMay 21, 2025,            Posted By: Maria Uebelhor
Last updated:May 21, 2025 ,

MLB Cincinnati Reds vs Pittsburgh Pirates Prediction 5/21

The Cincinnati Reds will meet the Pittsburgh Pirates at PNC Park on Wednesday, May 21, 2025. The game is set to start at 12:35 PM. Fans can look forward to this night game between these two teams.

Reds vs. Pirates Betting Prediction

  • Money Line Prediction: Reds MoneyLine: -125. The Reds have a balanced record and are playing against a struggling Pirates team. Their recent games show they can score and hold leads.
  • Over/Under Prediction: Under 8.0 (-110). Both teams have shown limited scoring in recent games, and the Pirates’ pitching has been effective at keeping scores low.

Team Trends

  • The Cincinnati Reds have a balanced season record of 25-25 with a slight edge at home, holding a 13-12 record.
  • The Pittsburgh Pirates have struggled this season with a record of 16-33 and are 13 games back in the NL Central.
  • In a recent spring training game on May 20th, the Pirates won against the Reds 1-0, with Bailey Falter allowing no runs in 7 innings.
  • On May 19th, the Reds defeated the Pirates 7-1, with Nick Lodolo striking out 7 batters over 6 innings.
  • Will Benson was a standout for the Reds against the Cleveland Guardians on May 18th, hitting 2 home runs and driving in 3 runs.

Reds vs Pirates Preview

The Cincinnati Reds will visit the Pittsburgh Pirates at PNC Park for a night game on Wednesday, May 21, 2025. Brady Singer will take the mound for the Reds. Singer has a record of 5-2 this season with a 5.01 ERA over 46 2/3 innings. He has 43 strikeouts and 18 walks, showing his ability to strike out batters.

On the other side, Andrew Heaney will pitch for the Pirates. Heaney has a 2-3 record with a 3.02 ERA in 50 2/3 innings this season. He has struck out 38 batters while walking 19. Fans can expect a competitive game with these two pitchers on the mound.

Pittsburgh Pirates: Key Players and Pitching Insights

Oneil Cruz is leading the Pirates in several hitting categories. He has hit 8 home runs and scored 24 runs. However, Cruz is dealing with back tightness and may not play. Bryan Reynolds is another strong hitter for the Pirates. He has 6 home runs and leads the team with 23 RBIs. Reynolds’ batting average is .206, but he remains a key player. Andrew McCutchen has played 43 games this season. He has a batting average of .243 and has hit 3 home runs. McCutchen adds depth to the Pirates’ lineup.

Cincinnati Reds: Key Players and Pitching Insights

Elly De La Cruz is having a standout season for the Reds. He has played in 50 games and leads the team with 8 home runs. De La Cruz also has 33 RBIs and has scored 32 runs. TJ Friedl is another key player for the Reds. He has a batting average of .280 and has hit 3 home runs. Friedl is dealing with a wrist injury but is expected to play. Matt McLain has contributed with 6 home runs and 17 RBIs. However, his batting average is .176, which is lower than expected. McLain has played 41 games this season.

Final Betting Pick

The Reds are favored with a MoneyLine of -125, and this seems like a solid pick. The Reds have a balanced record and have shown they can win both at home and on the road. Their recent games indicate they can score and maintain leads, which is crucial against a Pirates team with a poor record.

The Under 8.0 is also a reasonable choice. Both teams have struggled to score in recent games, and the Pirates’ pitching has been effective in keeping scores low. With Andrew Heaney’s ERA at 3.02, the game could see limited runs, making the Under a strong option.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.