Cincinnati Reds vs St. Louis Cardinals MLB Betting Prediction
PublishedSeptember 16, 2025,            Posted By: Maria Uebelhor
Last updated:September 16, 2025 ,

MLB Cincinnati Reds vs St. Louis Cardinals Prediction 9/16

The Cincinnati Reds will take on the St. Louis Cardinals on Tuesday, September 16, 2025, at 7:45 PM. The game will be held at Busch Stadium in St. Louis, MO. Fans can expect clear skies and a light breeze for this night game, which will be broadcast on FDSOH.

Reds vs. Cardinals Betting Prediction

  • Money Line Prediction: Cincinnati Reds -113. The Reds have a balanced record and recently won against the Cardinals, which gives them an edge in this game.
  • Over/Under Prediction: Over 8.0 (-111). Both teams have shown the ability to score runs, as seen in their recent high-scoring games.

Team Trends

  • The Cincinnati Reds have a road record of 35-41 this season.
  • The St. Louis Cardinals hold a home record of 41-35 this season.
  • In their last game on September 15th, the Reds defeated the Cardinals 11-6.
  • The Reds manager is Terry Francona, while the Cardinals are led by Oliver Marmol.
  • The Cardinals are ranked 4th in the NL Central, two games behind the Reds who are in 3rd place.

Reds vs Cardinals Preview

The Cincinnati Reds and St. Louis Cardinals are set for an exciting game at Busch Stadium. The Reds hold a 75-75 record and are ranked third in their division. They are coming off a win and have a 5-5 record in their last ten games. The Cardinals, with a 73-78 record, are fourth in the division. They are looking to bounce back after a loss and have struggled recently with a 3-7 record over their last ten games.

On the mound, Andrew Abbott will start for the Reds. He has an ERA of 2.79 and a WHIP of 1.13, with a 9-6 win-loss record. The Cardinals will counter with Michael McGreevy, who has a 4.44 ERA and a WHIP of 1.23. McGreevy’s win-loss record stands at 6-3. Fans can catch the game on FDSOH under clear skies with a light breeze.

Cardinals’ Key Players and Performance

The St. Louis Cardinals have some strong hitters this season. Willson Contreras leads the team with 20 home runs and 80 RBIs. Alec Burleson follows closely with 17 home runs and a .281 batting average.

Brendan Donovan and Iván Herrera add depth to the lineup. Donovan has a .283 batting average, while Herrera holds a .284 average. Both players contribute with over 10 home runs each.

On the mound, Michael McGreevy will start for the Cardinals. He has a 4.44 ERA and a 6-3 win-loss record. The team will look to improve their 21st ranked ERA of 4.33 in the league.

Reds Ready for the Challenge

Elly De La Cruz leads the Cincinnati Reds with 19 home runs and 98 runs. He holds a .263 batting average. Spencer Steer is another key player with 17 home runs and 64 RBIs. The Reds have a team batting average of .246. They rank 11th in the league in this category. Their on-base percentage is .316, placing them 12th. Andrew Abbott will start for the Reds. He has an ERA of 2.79 and a WHIP of 1.13. Abbott’s record stands at 9 wins and 6 losses.

Final Betting Pick

The Cincinnati Reds are a solid pick for the money line at -113. They recently won against the Cardinals, 11-6, showing strong hitting with 13 hits and 4 extra-base hits. Andrew Abbott, the Reds’ starting pitcher, has a lower ERA of 2.79 compared to the Cardinals’ Michael McGreevy, who has an ERA of 4.44. This gives the Reds an advantage on the mound.

The over/under prediction for this game is set at 8.0, and the over is a good choice. Both teams have shown they can score runs, with the Reds scoring 11 in their last game against the Cardinals. The Cardinals have also been part of high-scoring games, like their 9-8 loss to the Brewers. With both teams’ recent performances, a high-scoring game is likely.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.