The Cleveland Guardians will visit the Cincinnati Reds at Great American Ball Park on Friday, May 16, 2025. The game is set to start at 6:40 PM under the night sky. Fans can expect an exciting evening of baseball action.

Guardians vs. Reds Betting Prediction

• Money Line Prediction: Reds MoneyLine: +107. The Reds have a strong pitching staff with a 3.69 ERA, ranked 9th. Their hitting is also solid with a .239 average, which could give them an edge.
• Over/Under Prediction: Under 9.0 (-115). Both teams have solid pitching, and the Reds rank 9th in ERA. This suggests a lower-scoring game is likely.

Team Trends

• The Cleveland Guardians have a strong division record of 10-3 this season.
• The Cincinnati Reds have a slightly better road record at 11-12 compared to their home record of 10-12.
• On May 14th, the Cleveland Guardians lost to the Milwaukee Brewers with a score of 9-5, despite hitting two home runs.
• The Cincinnati Reds secured a 7-1 victory over the Chicago White Sox on May 15th, hitting three home runs in the game.
• José Ramírez has been a key hitter for the Cleveland Guardians, contributing in multiple recent games.

Guardians vs Reds Preview

The Cleveland Guardians are set to take on the Cincinnati Reds at Great American Ball Park. Tanner Bibee will be on the mound for the Guardians. He has a 3-3 record this season with an ERA of 3.80 over 45 innings.

Brady Singer will pitch for the Reds. Singer has a 4-2 record with a 4.97 ERA over 41 2/3 innings. Both teams are looking to improve their standings in this night game.

Reds Ready for Action

The Cincinnati Reds have some strong hitters this season. Elly De La Cruz leads the team with 8 home runs and 31 RBIs. He also has 30 runs, which is the highest on the team.

TJ Friedl is another key player for the Reds. He has a batting average of .274 and has scored 23 runs. Friedl is dealing with a wrist injury but is likely to play.

Matt McLain also contributes to the team’s offense. He has 6 home runs and 22 runs scored. Despite a lower batting average, McLain’s power is evident.

Guardians Gear Up for the Game

José Ramírez plays a big role for the Cleveland Guardians. His batting average is .295, with 8 home runs and 22 RBIs. Ramírez also has 23 runs, making him a leader in those areas. Steven Kwan stands out with a .325 batting average. He leads the team with 25 runs and has 17 RBIs. Kwan’s on-base percentage is .384, showing his ability to get on base. Kyle Manzardo adds power to the lineup. He has 10 home runs and 25 RBIs, both top on the team. His slugging percentage is .504, though his batting average is lower at .221.

Final Betting Pick

The Reds’ MoneyLine at +107 looks promising due to their strong pitching. With a 3.69 ERA, ranked 9th, their pitchers have been effective. Brady Singer, despite a 4.97 ERA, has a solid 4-2 record, showing he can secure wins.

For the Over/Under, the prediction is Under 9.0. Both teams have solid pitching, with the Reds ranking 9th in ERA. The Guardians’ offense has a .233 batting average, which is lower than the Reds’. This suggests a lower-scoring game is likely.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.