On Wednesday, August 20, 2025, the Cleveland Guardians will play against the Arizona Diamondbacks at Chase Field in Phoenix, AZ. The game will start at 3:40 PM and will be shown on ARID. The weather forecast predicts a very hot day with scattered clouds. The Guardians hold a 64-61 record, while the Diamondbacks have a 61-66 record. Both teams are looking to improve their standings in their respective divisions.

Guardians vs. Diamondbacks Betting Prediction

• Money Line Prediction: Cleveland Guardians +108. The Guardians have a better road record at 33-30 compared to the Diamondbacks’ home record of 31-31. This makes the Guardians a good value pick.
• Over/Under Prediction: Over 9.0 (-109). Both teams have shown the ability to score, as seen in their recent game where the Diamondbacks won 6-5. The Diamondbacks’ pitching ERA of 4.57 suggests runs could be plentiful.

Team Trends

• Cleveland Guardians have a road record of 33-30 this season.
• Arizona Diamondbacks have a home record of 31-31 this season.
• In their last game, Arizona Diamondbacks won 6-5 against the Cleveland Guardians.
• José Ramírez from the Cleveland Guardians hit a home run in the game on August 19th, 2025.
• Corbin Carroll from the Arizona Diamondbacks hit two triples in their last game against the Cleveland Guardians.

Guardians vs Diamondbacks Preview

The Cleveland Guardians are set to play the Arizona Diamondbacks at Chase Field. The Guardians have a record of 64-61 and are third in their division. They hope to bounce back from their recent loss. The Diamondbacks, with a record of 61-66, are fourth in their division and come into this game with a win in their last outing.

Parker Messick will start for the Guardians. The Diamondbacks will counter with Brandon Pfaadt, who has a 5.08 ERA and a 12-8 record. The game will take place on a very hot day with scattered clouds. Fans can watch the action on ARID at 3:40 PM.

Arizona Diamondbacks Ready for Action

The Arizona Diamondbacks have a strong lineup. Geraldo Perdomo leads the team in runs and RBIs. Ketel Marte stands out with a .293 batting average and 23 home runs. Brandon Pfaadt will start on the mound for the Diamondbacks. He has a record of 12 wins and 8 losses. His ERA is 5.08 and WHIP is 1.36. The team has a batting average of .251, ranking 6th in the league. They have 177 home runs, placing them 4th. Their on-base percentage is .324, which ranks 3rd in the league.

Cleveland Guardians Seek Victory

José Ramírez is a key player for the Cleveland Guardians. He has a batting average of .291, leading the team. Ramírez also has 26 home runs and 81 runs. Kyle Manzardo adds strength to the lineup. He has hit 21 home runs this season. His on-base percentage is .319. The Guardians have a team batting average of .227, ranked 20th. They have hit 132 home runs, placing 19th in the league. Their on-base percentage is .298, ranking 18th.

Final Betting Pick

The Cleveland Guardians are a strong pick for the money line at +108. Their road record of 33-30 is better than the Arizona Diamondbacks’ home record of 31-31. This gives the Guardians an edge when playing away from home.

Taking the over on 9.0 runs is a smart choice. Both teams have shown they can score, as seen in their recent 6-5 game. The Diamondbacks’ pitching ERA of 4.57 indicates that runs could be frequent in this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.