Cleveland Guardians vs Washington Nationals MLB Betting Prediction

MLB Guardians vs Washington Nationals Prediction 5/6

On Tuesday, May 06, 2025, the Cleveland Guardians will take on the Washington Nationals at Nationals Park. The game is set to start at 3:35 PM under the lights of a night game. Fans can look forward to an exciting matchup between these two teams.

Guardians vs. Nationals Betting Prediction

  • Money Line Prediction: Guardians MoneyLine: -119. The Guardians have a better record and strong division performance. Their recent games show consistent hitting, making them a good choice.
  • Over/Under Prediction: Over 9.0 (-107). Both teams have shown the ability to score runs, and with the Nationals’ higher ERA, the game could see plenty of scoring.

Team Trends

  • The Cleveland Guardians have a strong division record of 10-3 this season.
  • The Washington Nationals have a road record of 7-12 this season.
  • In a recent game, the Cleveland Guardians defeated the Toronto Blue Jays 5-4 with 10 hits.
  • The Washington Nationals recently won against the Philadelphia Phillies 4-2 with 6 hits.
  • Gabriel Arias of the Cleveland Guardians went 3 for 4 with 2 RBIs in a game against the Toronto Blue Jays.

Guardians vs Nationals Preview

The Cleveland Guardians will travel to Nationals Park to play the Washington Nationals on Tuesday, May 6, 2025. The game begins at 3:35 PM and will be played under the stadium lights. The Guardians will rely on Luis L. Ortiz, who has a record of 2-3 this season with an ERA of 4.78. Ortiz has pitched 32 innings in six starts and has struck out 36 batters.

The Nationals will have Jake Irvin on the mound. Irvin has a 2-1 record this season with an ERA of 4.01. He has pitched 42 2/3 innings in seven starts, striking out 33 batters. The matchup will see two right-handed pitchers aiming to lead their teams to a win. Fans can expect a competitive game as these teams face each other.

Washington Nationals: Key Players and Pitching Insights

The Washington Nationals have some standout hitters this season. James Wood leads the team with a .273 batting average and nine home runs. He also ranks first in the league for runs with 21.

Nathaniel Lowe is another important player for the Nationals. He has played 35 games, hitting six home runs and driving in 27 runs. His RBI count is the highest on the team and in the league.

On the pitching side, Jake Irvin is the starting pitcher for the Nationals. He has a 2-1 record with a 4.01 ERA over 42 2/3 innings. Irvin has struck out 33 batters and walked 11 this season.

Cleveland Guardians: Key Players and Pitching Overview

Steven Kwan has been a standout for the Cleveland Guardians. He has a .333 batting average with four home runs. Kwan also leads the team and league in runs with 20. Kyle Manzardo is another key player for the Guardians. He has played 31 games, hitting eight home runs. Manzardo has driven in 20 runs, leading both the team and the league. Luis L. Ortiz takes the mound for the Guardians. Ortiz has a 2-3 record with a 4.78 ERA over 32 innings. He has struck out 36 batters and walked 16 this season.

Final Betting Pick

The Guardians are favored on the money line at -119, and this is a solid pick. They have a strong division record of 10-3 and a better overall record than the Nationals. Their recent performance shows consistent hitting, with key players like Steven Kwan and Kyle Manzardo contributing to their success.

For the over/under, the line is set at 9.0, and the over is a reasonable choice. Both teams have shown they can score runs, and the Nationals’ higher ERA of 5.08 suggests more runs could be scored. The Guardians’ recent games have seen a good amount of hits and runs, supporting the over prediction.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.