Houston Astros vs Pittsburgh Pirates MLB Betting Prediction
PublishedJune 4, 2025,            Posted By: Maria Uebelhor
Last updated:June 4, 2025 ,

MLB Houston Astros vs Pittsburgh Pirates Prediction 6/4

On Wednesday, June 4, 2025, the Houston Astros will visit the Pittsburgh Pirates at PNC Park in Pittsburgh, PA. The Astros have a season record of 33-27, while the Pirates hold a 22-39 record. The night game will start at 6:40 PM and will be broadcast on SCHN.

Astros vs. Pirates Betting Prediction

  • Money Line Prediction: Houston Astros MoneyLine at -142. The Astros have a better overall record and recently won against the Pirates. The Pirates have struggled at home with a 13-17 record.
  • Over/Under Prediction: Over 8.5. Both starting pitchers have high ERAs, with Mike Burrows at 8.64 and Ryan Gusto at 4.62, suggesting potential for more runs.

Team Trends

  • The Houston Astros have a road record of 11-15 this season.
  • The Pittsburgh Pirates have a home record of 13-17 this season.
  • In the last game on June 3rd, 2025, the Astros won against the Pirates with a score of 3-0.
  • Lance McCullers Jr. pitched 6 innings with 7 strikeouts for the Astros in the last game against the Pirates.
  • Paul Skenes pitched 8 innings with 8 strikeouts for the Pirates in the last game against the Astros.

Astros vs Pirates Preview

The Houston Astros will take on the Pittsburgh Pirates at PNC Park on Wednesday night. The Astros enter the game with a record of 33-27. They aim to continue their winning ways against the Pirates, who hold a 22-39 record. The game is set for 6:40 PM, and fans can catch it on SCHN.

Ryan Gusto will start for the Astros. He has a 4.62 ERA and a 3-2 record this season. On the other side, Mike Burrows will pitch for the Pirates. His ERA is 8.64, and he has a 0-1 record. Both pitchers will look to make an impact as they take the mound under the lights at PNC Park.

Pirates’ Key Players and Challenges

The Pittsburgh Pirates have some hitters to watch. Andrew McCutchen leads the team with 5 home runs. His batting average is .258, and he has 18 RBIs. Isiah Kiner-Falefa has a batting average of .310. He has played 49 games and scored 21 runs. His on-base percentage is .356, which is solid for the team. Mike Burrows will start on the mound for the Pirates. His ERA is 8.64, and he has a WHIP of 1.56. He is looking for his first win of the season.

Astros’ Lineup and Pitching Overview

The Houston Astros have a strong lineup. Jeremy Peña is one of their top hitters. He has a batting average of .308 and has hit 9 home runs in 60 games. Isaac Paredes leads the team with 12 home runs and 34 RBIs. Ryan Gusto will pitch for the Astros. His ERA is 4.62, and his WHIP is 1.56. He has 3 wins and 2 losses this season. The Astros have a team batting average of .252. They have hit 61 home runs and have a slugging percentage of .391. Their pitching staff has an ERA of 3.59, which ranks 10th in the league.

Final Betting Pick

The Astros’ MoneyLine at -142 looks favorable due to their recent win against the Pirates and a better overall record. Houston’s road record might not be strong, but the Pirates have struggled at home with a 13-17 record. This gives the Astros an edge, especially with their recent performance against Pittsburgh.

The Over 8.5 prediction seems reasonable given the high ERAs of both starting pitchers. Mike Burrows has an ERA of 8.64, and Ryan Gusto has an ERA of 4.62. These numbers suggest that both teams could score more runs, making the over a solid choice for this game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.