Los Angeles Dodgers vs Chicago Cubs MLB Betting Prediction

MLB Los Angeles Dodgers vs Chicago Cubs Prediction 4/22

The Los Angeles Dodgers will play against the Chicago Cubs at Wrigley Field on Tuesday, April 22, 2025. The game is set to start at 7:40 PM during the night. Fans can expect an exciting game as these two teams meet on the field.

Dodgers vs. Cubs Betting Prediction

  • Money Line Prediction: Cubs MoneyLine: 103. The Cubs have a strong hitting lineup and a solid recent performance. With Ohtani out for the Dodgers, the Cubs have a good chance to win.
  • Over/Under Prediction: Over 8.0 (-118). Both teams have strong offenses, and the Cubs’ pitching has a higher ERA, suggesting more runs will be scored.

Team Trends

  • The Los Angeles Dodgers have a strong home record this season, standing at 10-2.
  • Chicago Cubs have performed well on the road with an 8-5 record this season.
  • Yoshinobu Yamamoto of the Dodgers pitched 7 innings with 10 strikeouts against the Texas Rangers on April 18th, 2025.
  • Carson Kelly of the Cubs hit two home runs and had 5 RBIs against the Arizona Diamondbacks on April 18th, 2025.
  • Freddie Freeman hit a home run and had 2 RBIs in the Dodgers’ game against the Texas Rangers on April 19th, 2025.

Dodgers vs Cubs Preview

The Dodgers and Cubs are ready to meet at Wrigley Field on Tuesday night. Dustin May will take the mound for the Dodgers. He has a strong start to the season with a 1.06 ERA over 17 innings. May’s recent performance against the Rockies showed his ability to limit hits and keep runs low.

On the other side, Shota Imanaga will pitch for the Cubs. Imanaga holds a 2.22 ERA in 28 1/3 innings this season. His last game against the Padres saw him strike out seven batters while allowing only one earned run. Both teams will rely on their starters to set the tone early in the game.

Chicago Cubs: Power at the Plate

The Chicago Cubs are showing strength in hitting this season. Kyle Tucker leads the team with a .302 batting average and tops the league with six home runs. He also leads in runs and RBIs, making him a key player for the Cubs.

Pete Crow-Armstrong has also been important for the Cubs. He has a .258 batting average and ranks third on the team in runs. His contributions help keep the Cubs competitive in every game.

Michael Busch adds depth to the Cubs’ lineup. With a .316 batting average, he ranks second on the team in home runs. His ability to drive in runs is crucial for the Cubs’ success.

Los Angeles Dodgers: Aiming for Consistency

The Dodgers have been solid with their bats. Tommy Edman leads the team with seven home runs. He also has a .261 batting average, making him a strong presence in the lineup. His 15 RBIs rank second on the team. Teoscar Hernández is another key player for the Dodgers. He has five home runs and leads the team with 17 RBIs. His batting average is .250, and he is working through an illness that may affect his play. Dustin May will take the mound for the Dodgers. He has a 1.06 ERA over three games this season. In his last game against the Rockies, he allowed only one run over six innings.

Final Betting Pick

The Cubs have a strong hitting lineup, ranking high in batting average, on-base percentage, and slugging percentage. Their ability to get on base and hit for power gives them an edge, especially with Shohei Ohtani out for the Dodgers. Kyle Tucker and Michael Busch are key players for the Cubs, with impressive stats in home runs and RBIs.

On the other hand, the Dodgers’ pitching is solid, but the absence of Ohtani might impact their run production. Dustin May has a low ERA, but the Cubs’ offense could challenge him. With both teams having strong offenses and the Cubs’ pitching showing a higher ERA, the over 8.0 bet looks promising for this game.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.