New York Yankees vs Cleveland Guardians MLB Betting Prediction

MLB New York Yankees vs Cleveland Guardians Prediction 4/21

On Monday, April 21, 2025, the New York Yankees will play against the Cleveland Guardians at Progressive Field. The game is set to begin at 6:10 PM and will be a night game. Fans can expect an exciting evening as these two teams meet on the field.

Yankees vs. Guardians Betting Prediction

  • Money Line Prediction: Yankees MoneyLine -120. The Yankees have a better record and strong hitting stats, with Aaron Judge leading in multiple categories. Their pitching also shows a lower batting average against compared to the Guardians.
  • Over/Under Prediction: Under 8.5 (-112). Both teams have similar ERA stats, but the Yankees’ pitching has been solid, and the Guardians have struggled with batting average and on-base percentage.

Team Trends

  • The New York Yankees have a division record of 3-1 this season.
  • The Cleveland Guardians have a strong division record of 7-2.
  • In their recent game, the Yankees won 4-0 against the Tampa Bay Rays with three home runs.
  • The Guardians recently won 5-4 against the Pittsburgh Pirates with two home runs.
  • Yankees’ Max Fried pitched 7 2/3 innings with zero earned runs in his last game.

Yankees vs Guardians Preview

The Yankees and Guardians are set to meet at Progressive Field on April 21, 2025. The Yankees will have Clarke Schmidt on the mound. In his last game against the Royals, Schmidt pitched 5 2/3 innings and allowed 3 earned runs. His ERA for the season stands at 4.76.

The Guardians will counter with Gavin Williams. Williams has pitched 19 2/3 innings this season with an ERA of 4.58. In his recent outing against the Orioles, he allowed 5 earned runs over 6 2/3 innings. The game begins at 6:10 PM, making it a night game under the lights.

Cleveland Guardians: Key Players and Stats

Steven Kwan is having a strong start this season. He has played 21 games with a batting average of .325. Kwan leads the team with 14 runs and is second in home runs with 4. Kyle Manzardo is making an impact with his power at the plate. He has hit 6 home runs, which is the most on the team. Manzardo also leads the team in RBIs with 16, showing his ability to drive in runs. José Ramírez contributes with solid hitting and fielding. He has a batting average of .268 and has hit 4 home runs. Ramírez has also scored 9 runs and driven in 9 RBIs, adding depth to the lineup.

Yankees’ Power at the Plate and on the Mound

Aaron Judge is leading the Yankees with impressive stats. He has played 22 games and holds a batting average of .390. Judge leads the league in home runs with 7 and has driven in 25 runs, making him a key player for the team. Jazz Chisholm Jr. has shown power with 6 home runs. However, his batting average is .157, which is lower than expected. Chisholm Jr. is currently dealing with a suspension but can still play during the appeal process. Ben Rice has been a solid contributor for the Yankees. With a batting average of .292, he has hit 5 home runs and driven in 9 runs. Rice is currently dealing with an elbow injury, which may affect his availability.

Final Betting Pick

The Yankees are favored on the money line at -120, and this pick seems solid given their current form. They have a 14-8 record, with strong performances at home and on the road. Aaron Judge is a key player, leading the league in several hitting categories, which boosts the Yankees’ chances.

The under 8.5 total runs is another good choice. Both teams have similar ERA stats, but the Yankees’ pitching has been more effective, with a lower batting average against. The Guardians have struggled with batting average and on-base percentage, which could limit their scoring opportunities.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.