Pittsburgh Pirates vs St. Louis Cardinals MLB Betting Prediction

MLB Pittsburgh Pirates vs St. Louis Cardinals Prediction 5/5

The Pittsburgh Pirates will visit the St. Louis Cardinals at Busch Stadium on Monday, May 05, 2025. The game is set to start at 7:45 PM and will take place under the night sky. Fans can expect an exciting game as these two teams meet on the field.

Pirates vs. Cardinals Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine: -146. The Cardinals have a better home record and stronger hitting stats. Their pitching stats are also slightly better than the Pirates.
  • Over/Under Prediction: Under 8.5 (-117). Both teams have struggled offensively in recent games, and the starting pitchers have shown they can limit runs.

Team Trends

  • The Pittsburgh Pirates have a record of 12-23 this season, with 9 games back in the NL Central.
  • The St. Louis Cardinals have a home record of 12-6, while their road record stands at 4-13.
  • In their recent game against the San Diego Padres, the Pittsburgh Pirates had 8 hits but failed to score any runs.
  • The St. Louis Cardinals won against the New York Mets 5-4 with Alec Burleson hitting a home run.
  • On April 30th, the St. Louis Cardinals defeated the Cincinnati Reds 9-1, with Steven Matz pitching 4 scoreless innings.

Pirates vs Cardinals Preview

The Pittsburgh Pirates are set to play the St. Louis Cardinals at Busch Stadium on May 5, 2025. The game begins at 7:45 PM, and both teams are ready for action. The Pirates will have Carmen Mlodzinski on the mound. He has a 1-3 record with an ERA of 6.58 over six starts this season.

For the Cardinals, Miles Mikolas will take the ball. Mikolas has a 1-2 record and an ERA of 4.66 in his six starts. Both pitchers will aim to improve their records in this game. Fans will be watching to see how these pitchers perform under the lights.

Cardinals’ Key Players and Stats

Lars Nootbaar leads the Cardinals in several areas. He has played 34 games with a batting average of .244. Nootbaar has hit 5 home runs and scored 23 runs, both ranking first on the team. Brendan Donovan is another top performer for the Cardinals. In 33 games, he boasts a batting average of .339. Donovan leads the team with 19 RBIs and has scored 19 runs. Victor Scott II also contributes significantly to the team’s offense. He has a batting average of .286 in 31 games. Scott has hit 2 home runs and brought in 15 RBIs for the team.

Pirates’ Top Performers and Season Overview

Oneil Cruz leads the Pirates with his strong performance. In 32 games, he has a batting average of .243. Cruz ranks first in the league and team with 8 home runs and 20 runs. Bryan Reynolds also plays a key role for the Pirates. He has a batting average of .232 over 34 games. Reynolds is second on the team with 4 home runs and 17 RBIs. Andrew McCutchen adds depth to the lineup. He has a batting average of .263 in 29 games. McCutchen has hit 3 home runs and driven in 12 RBIs.

Final Betting Pick

The Cardinals are favored on the money line at -146, which reflects their stronger home performance and hitting stats. With a home record of 12-6, they have shown they can play well in front of their fans. The Pirates, on the other hand, have struggled on the road with a 5-11 record. The Cardinals’ hitting stats, including a .259 batting average and 67 doubles, rank higher than the Pirates, making them a solid pick.

For the over/under prediction, the under 8.5 at -117 looks promising. Both teams have had trouble scoring in recent games, with the Pirates scoring just 4 runs in their last two games. The starting pitchers, Miles Mikolas and Carmen Mlodzinski, have shown they can limit runs, with Mikolas having a better ERA at 4.66 compared to Mlodzinski’s 6.58. This suggests a lower-scoring game, making the under a good choice.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.