Pittsburgh Pirates vs St. Louis Cardinals MLB Betting Prediction

MLB Pittsburgh Pirates vs St. Louis Cardinals Prediction 5/6

On Tuesday, May 06, 2025, the Pittsburgh Pirates will take on the St. Louis Cardinals at Busch Stadium. The game is set for 7:45 PM and will be played under the lights. Fans can expect an exciting evening as these teams meet on the field.

Pirates vs. Cardinals Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine: 114. The Cardinals have a better overall record and a strong home performance, which makes them a good value as the underdog.
  • Over/Under Prediction: Over 7.0 (-118). Both teams have shown they can score, and the Cardinals’ recent games have seen high run totals.

Team Trends

  • The Pittsburgh Pirates have a regular season record of 12-24 and are 10 games back in the NL Central.
  • The St. Louis Cardinals hold a regular season record of 17-19, placing them 5 games back in the NL Central.
  • In their recent game on May 5th, 2025, the Cardinals defeated the Pirates 6-3 in a spring training game.
  • During this game, the Cardinals hit 3 home runs compared to the Pirates’ 1.
  • The Cardinals’ home record is 13-6, while their road record is 4-13.

Pirates vs Cardinals Preview

As the Pittsburgh Pirates visit the St. Louis Cardinals on Tuesday, fans will have their eyes on the starting pitchers. Paul Skenes will take the mound for the Pirates. Skenes has started seven games this season, earning a 3-3 record with a 2.74 ERA. He has struck out 41 batters over 42 2/3 innings, showing strong control with only eight walks.

On the other side, Matthew Liberatore will pitch for the Cardinals. Liberatore has a 2-3 record with a 3.44 ERA in his six starts. He has pitched 34 innings and struck out 30 batters while walking just three. Both pitchers will aim to give their team an edge in this evening game at Busch Stadium. Fans can look forward to seeing how these pitchers perform under the lights.

Cardinals Ready for the Next Game

The St. Louis Cardinals have a strong lineup this season. Lars Nootbaar leads with a .237 batting average and tops the team with 5 home runs. Brendan Donovan is not far behind, hitting .336 and leading in RBIs with 19. Victor Scott II also contributes with a .284 batting average and 15 RBIs. The team as a whole has a .261 batting average, ranking second in the league. Their slugging percentage stands at .404, placing them ninth. Matthew Liberatore will start as the pitcher for the Cardinals. He has a 2-3 record with a 3.44 ERA over 34 innings. His WHIP is .97, and he has struck out 30 batters this season.

Pirates Aim to Improve on the Road

The Pittsburgh Pirates have key players leading their lineup. Oneil Cruz stands out with a .252 batting average and 8 home runs. Bryan Reynolds supports with 5 home runs and 19 RBIs. Andrew McCutchen adds depth, hitting .253 with 12 RBIs. The team has a .223 batting average, placing them 23rd in the league. Their on-base percentage is .306, and they have hit 26 home runs. They are strong in stolen bases, ranking 5th with 39. Paul Skenes will start as the pitcher for the Pirates. He has a 3-3 record with a 2.74 ERA over 42 2/3 innings. Skenes has 41 strikeouts and a WHIP of .91 this season.

Final Betting Pick

The Cardinals have a strong home record of 13-6, which supports the MoneyLine pick. They have been performing well at home, and their recent win against the Pirates adds confidence to this choice. The Pirates, with a road record of 5-12, struggle away from home, making the Cardinals a good value as the underdog.

For the Over 7.0 prediction, both teams have shown they can score runs. The Cardinals have a .261 batting average, ranking second, and have hit 35 home runs. The Pirates’ pitching has a 4.33 ERA, which is ranked 23rd, suggesting they may allow several runs. This combination of factors supports the expectation of a high-scoring game.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.