San Diego Padres vs St. Louis Cardinals MLB Betting Prediction
PublishedJuly 25, 2025,            Posted By: Maria Uebelhor
Last updated:July 25, 2025 ,

MLB San Diego Padres vs St. Louis Cardinals Prediction 7/25

The San Diego Padres will visit the St. Louis Cardinals on Friday, July 25, 2025. The game will take place at Busch Stadium in St. Louis, MO, starting at 7:15 PM. Fans can catch the action on FDSMW as the teams play under night skies with broken clouds and a light breeze. The Padres have a record of 55-48, while the Cardinals hold a 53-51 record this season.

Padres vs. Cardinals Betting Prediction

  • Money Line Prediction: San Diego Padres -141. The Padres have a strong starting pitcher in Nick Pivetta, who has a 10-2 record and a 2.81 ERA. The Cardinals’ starting pitcher, Miles Mikolas, has a higher ERA at 5.20, which could favor the Padres.
  • Over/Under Prediction: Over 8.5 (-106). Both teams scored a combined 16 runs in their last game against each other. With the Cardinals’ pitching struggles, there is potential for a high-scoring game.

Team Trends

  • The San Diego Padres have a road record of 24-30 this season.
  • The St. Louis Cardinals have a home record of 30-20 this season.
  • In their last game, the Cardinals won 9-7 against the Padres.
  • The Padres’ manager is Mike Schildt, while the Cardinals’ manager is Oliver Marmol.
  • The game will be played at Busch Stadium, with a weather forecast of broken clouds and a light breeze.

Padres vs Cardinals Preview

The San Diego Padres are set to play against the St. Louis Cardinals at Busch Stadium on Friday. The Padres have a record of 55-48, while the Cardinals stand at 53-51. The game will start at 7:15 PM, and fans can watch it on FDSMW. The weather forecast predicts a very hot day with broken clouds and a light breeze.

Nick Pivetta will take the mound for the Padres. He has an ERA of 2.81 and a WHIP of 1.00 with a 10-2 record. The Cardinals will counter with Miles Mikolas, who has an ERA of 5.20 and a WHIP of 1.30, holding a 5-7 record. Both teams will look to their pitchers to set the tone for the game.

Cardinals’ Key Players and Performance

The St. Louis Cardinals have some strong hitters this season. Willson Contreras leads the team with 14 home runs and 61 RBIs. Brendan Donovan follows with a .296 batting average and 54 runs scored. Alec Burleson has also been effective with a .289 batting average and 12 home runs. Masyn Winn has contributed with 57 runs and 34 RBIs. Nolan Arenado has added 10 home runs to the team’s total. On the pitching side, Miles Mikolas will start for the Cardinals. He has an ERA of 5.20 and a WHIP of 1.30. Mikolas has a record of 5 wins and 7 losses this season.

Padres’ Power and Pitching Strengths

Manny Machado leads the San Diego Padres with 19 home runs and 63 RBIs. He has a batting average of .289 and has played in 103 games this season. Xander Bogaerts adds to the lineup with a .267 batting average and 44 runs. Luis Arraez has been consistent with a .288 batting average. He has contributed 38 RBIs and 44 runs. Jake Cronenworth has hit 8 home runs and scored 31 runs in 78 games. Nick Pivetta will be the starting pitcher for the Padres. He has a strong record with 10 wins and 2 losses. Pivetta has an ERA of 2.81 and a WHIP of 1.00.

Final Betting Pick

The Padres are favored on the money line at -141. Nick Pivetta’s impressive 10-2 record with a 2.81 ERA gives the Padres a strong edge. Pivetta’s recent performance against the Nationals, where he allowed only one run over six innings, shows his ability to control games on the road.

The over/under is set at 8.5, and the over is a solid pick. Both teams combined for 16 runs in their last game, indicating potential for another high-scoring game. The Cardinals’ pitching has struggled, with Miles Mikolas holding a 5.20 ERA, which could lead to more runs from the Padres’ lineup.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.