San Diego Padres vs Toronto Blue Jays MLB Betting Prediction
PublishedMay 21, 2025,            Posted By: Maria Uebelhor
Last updated:May 21, 2025 ,

MLB San Diego Padres vs Toronto Blue Jays Prediction 5/21

The San Diego Padres will travel to face the Toronto Blue Jays at Rogers Centre. This game is set for Wednesday, May 21, 2025, with a start time of 7:07 PM. Fans can look forward to an exciting night game between these two teams.

Padres vs. Blue Jays Betting Prediction

  • Money Line Prediction: Padres MoneyLine: 130. The Padres have a better record this season and strong performances from top hitters like Fernando Tatis Jr. and Manny Machado. Their pitching stats are also solid, with a lower ERA than the Blue Jays.
  • Over/Under Prediction: Under 8.5 (-101). Both teams have shown average offensive stats, and with Randy Vásquez and Kevin Gausman on the mound, the game might not see high scoring.

Team Trends

  • The San Diego Padres have a strong division record this season with 7 wins and 1 loss.
  • The Toronto Blue Jays have a home record of 14 wins and 12 losses this season.
  • In a recent game, the Padres’ Dylan Cease pitched 7 innings, allowing 3 hits and 3 runs.
  • Chris Bassitt of the Blue Jays pitched 6 innings against the Padres, allowing no runs.
  • Vladimir Guerrero Jr. hit a home run in the Blue Jays’ game against the Padres on May 20th, 2025.

Padres vs Blue Jays Preview

The San Diego Padres head to Rogers Centre to take on the Toronto Blue Jays. Randy Vásquez will start for the Padres. He has a 3-3 record with a 3.45 ERA over 44 1/3 innings. He has not played recently, but he looks to make an impact in this game. His control will be key, as he has walked 26 batters this season.

Kevin Gausman will take the mound for the Blue Jays. He has a 3-4 record with a 4.59 ERA in 51 innings. Gausman has struck out 46 batters and walked 12. He will aim to improve his record and help the Blue Jays secure a win at home.

Toronto Blue Jays: Key Players and Stats

The Toronto Blue Jays have a strong lineup, led by Vladimir Guerrero Jr. He has played 47 games with a batting average of .289. Guerrero leads the team in home runs with 6 and has scored 27 runs, both ranking first in the league. Bo Bichette is another key player for the Blue Jays. He also played 47 games and holds a .286 batting average. Bichette has 22 RBIs, which ranks first on the team and in the league. George Springer adds depth to the Blue Jays’ lineup. In 44 games, he has a .257 batting average. Springer’s 5 home runs place him second on the team and in the league.

San Diego Padres: Power at the Plate

Fernando Tatis Jr. is a standout player for the Padres. He has played in 45 games and has a batting average of .303. Tatis leads the league and team with 12 home runs, 37 runs, and 27 RBIs. Manny Machado is another key player for the Padres. He has a .310 batting average over 46 games. Machado has 3 home runs and has scored 32 runs, ranking second on the team. Xander Bogaerts adds strength to the Padres’ lineup. In 46 games, he has a batting average of .247. Bogaerts has 3 home runs and 20 RBIs, placing him third on the team.

Final Betting Pick

The Padres have a strong case for the MoneyLine pick. They hold a better record this season at 27-19 compared to the Blue Jays’ 23-24. Key players like Fernando Tatis Jr. and Manny Machado are performing well, with Tatis leading in home runs and runs. Their pitching also stands out with a lower ERA of 3.39, ranking 8th in the league.

The Under 8.5 prediction is supported by both teams’ average offensive stats. The Padres rank 12th in slugging percentage, while the Blue Jays rank 17th. With Randy Vásquez and Kevin Gausman starting, both with solid pitching records, the game might not see high scoring. Vásquez has an ERA of 3.45, and Gausman has a WHIP of 1.06, indicating a potential low-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.