Seattle Mariners vs Chicago White Sox MLB Betting Prediction
PublishedMay 21, 2025,            Posted By: Maria Uebelhor
Last updated:May 21, 2025 ,

MLB Seattle Mariners vs Chicago White Sox Prediction 5/21

The Seattle Mariners will play against the Chicago White Sox at Rate Field on Wednesday, May 21, 2025. The game is set to start at 2:10 PM. Fans can look forward to an exciting night game under the lights.

Mariners vs. White Sox Betting Prediction

  • Money Line Prediction: Mariners MoneyLine: -157. The Mariners have a better record and stronger recent performance. Their hitting and pitching stats are also superior to the White Sox.
  • Over/Under Prediction: Under 8.0 (-105). Both teams have strong starting pitchers with low ERAs, suggesting a lower-scoring game.

Team Trends

  • The Seattle Mariners have a division record of 13-5 this season.
  • The Chicago White Sox have a road record of 5-21 this season.
  • In a recent game, Luis Castillo of the Mariners pitched 7 innings, allowing no runs against the White Sox.
  • Miguel Vargas of the White Sox hit 2 home runs in a game against the Cubs on May 16th, 2025.
  • The Mariners have won their last four spring training games, including a 5-1 win against the White Sox.

Mariners vs White Sox Preview

The Seattle Mariners will take on the Chicago White Sox at Rate Field on May 21, 2025. The game is scheduled for 2:10 PM, and fans will enjoy the action under the lights. Logan Evans will start on the mound for the Mariners. He has a 2-1 record with a 2.57 ERA this season. Evans has pitched 21 innings in four starts.

Shane Smith will pitch for the White Sox. He has a 1-3 record with a 2.05 ERA. Smith has been consistent, pitching 48 1/3 innings in nine starts. Both teams will rely on their pitchers to set the tone for the game. Fans can expect a competitive game between these two teams.

Chicago White Sox: Key Players and Performance

The Chicago White Sox have a few standout hitters this season. Luis Robert Jr. has played 45 games with a batting average of .182. He is leading the team in runs with 21 and ranks second in the league.

Miguel Vargas is another key player for the White Sox. He has a batting average of .240 over 46 games. Vargas leads the team in home runs with 6 and RBIs with 21.

On the pitching side, Shane Smith is the starting pitcher for the White Sox. He has pitched in 9 games with a record of 1-3. Smith’s ERA is 2.05, and he has struck out 43 batters.

Seattle Mariners: Power at the Plate

Cal Raleigh is a key player for the Mariners this season. He has played 47 games with a batting average of .241. Raleigh leads the league in home runs with 15 and runs with 31. Julio Rodríguez is another strong hitter for Seattle. His batting average is .232 over 47 games. Rodríguez has hit 8 home runs and shares the league lead in runs with Raleigh. Randy Arozarena adds depth to the lineup. He has a batting average of .230 in 45 games. Arozarena has hit 6 home runs and scored 21 runs this season.

Final Betting Pick

The Mariners are a strong pick for the MoneyLine at -157. They have a better overall record of 27-20 compared to the White Sox’s 15-34. The Mariners also perform well on the road, with a 14-9 record, while the White Sox struggle at home, going 10-13. The Mariners’ hitting stats, including 63 home runs, rank them 5th in the league, showing their ability to score runs.

Choosing Under 8.0 (-105) for the game is a good option. Both starting pitchers have low ERAs, with Logan Evans at 2.57 and Shane Smith at 2.05. This suggests a lower-scoring game. The Mariners have a solid team ERA of 3.61, ranking 11th, which supports the prediction of fewer runs being scored. The White Sox’s batting average of .216 ranks them 23rd, indicating they might struggle against the Mariners’ pitching.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.