Seattle Mariners vs Houston Astros MLB Betting Prediction
PublishedMay 22, 2025,            Posted By: Maria Uebelhor
Last updated:May 22, 2025 ,

MLB Seattle Mariners vs Houston Astros Prediction 5/22

The Seattle Mariners will play against the Houston Astros on Thursday, May 22, 2025. The game will take place at Daikin Park and is set to start at 8:10 PM. Fans can look forward to a night game as the Mariners visit the Astros.

Mariners vs. Astros Betting Prediction

  • Money Line Prediction: Mariners MoneyLine: -138. The Mariners have a strong division record and have been performing well on the road. George Kirby’s pitching stats are not available, but Lance McCullers Jr. has struggled with a high ERA and WHIP.
  • Over/Under Prediction: Under 8.5 (-109). Both teams have solid pitching stats, with the Astros having a low ERA and WHIP. This suggests a lower-scoring game.

Team Trends

  • The Seattle Mariners have a strong division record of 13-5 this season.
  • Houston Astros have a home record of 15-9, matching the Mariners’ road record.
  • In their recent game against the Chicago White Sox, the Mariners hit three home runs.
  • Isaac Paredes hit two home runs for the Astros in their recent game against the Tampa Bay Rays.
  • The Mariners have won their last five spring training games.

Mariners vs Astros Preview

The Seattle Mariners will travel to Daikin Park to play the Houston Astros on Thursday night. The Mariners have George Kirby as their starting pitcher. Kirby has not yet played this season, so fans will be eager to see how he performs.

Lance McCullers Jr. will pitch for the Astros. He has started in three games this season, with an ERA of 7.88. McCullers aims to improve his stats and help the Astros secure a win at home.

Houston Astros: Home Team Overview

The Houston Astros have some strong hitters this season. Isaac Paredes leads the team with a .270 batting average and 10 home runs. Jeremy Peña and Jake Meyers also contribute with solid numbers, making the lineup balanced. The Astros’ team batting average is .246, placing them 13th in the league. They have hit 45 home runs, ranking 14th. Their on-base percentage is .317, which is 11th in the standings. Lance McCullers Jr. will start on the mound for the Astros. He has played three games this season with an ERA of 7.88. The Astros’ pitching staff has a team ERA of 3.48, which ranks 7th in the league.

Seattle Mariners: Away Team Insights

The Seattle Mariners have some strong hitters in their lineup. Cal Raleigh is leading with a .249 batting average and 16 home runs. Julio Rodríguez adds to the mix with 9 home runs and 32 runs. Randy Arozarena contributes with 6 home runs. The Mariners’ team batting average is .236, which ranks 17th in the league. Their on-base percentage is .324, placing them 8th. They have hit 66 home runs, ranking 6th in the league. George Kirby is set to pitch for the Mariners. There are no current stats available for Kirby this season. The Mariners’ pitching staff has a team ERA of 3.62, ranking 11th in the league.

Final Betting Pick

The Mariners are a good pick for the Money Line at -138. They have a strong division record of 13-5 and perform well on the road with a 15-9 record. Lance McCullers Jr. has struggled with a high ERA of 7.88 and WHIP of 2.12, which could give the Mariners an advantage.

The Under 8.5 bet is also a solid choice. Both teams have strong pitching stats, with the Astros having a low ERA of 3.48 and WHIP of 1.14. This suggests the game could be lower-scoring, aligning with the Under 8.5 prediction.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.