The St. Louis Cardinals will play against the Baltimore Orioles on Wednesday, May 28, 2025. The game will take place at Oriole Park at Camden Yards. It is set to start at 6:35 PM under the night sky.

Cardinals vs. Orioles Betting Prediction

• Money Line Prediction: Cardinals +104. The Cardinals have a better overall record and stronger pitching with Miles Mikolas, who has a lower ERA than Cade Povich of the Orioles.
• Over/Under Prediction: Over 8.0 (-114). Both teams have shown the ability to score runs in recent games, and the Orioles’ pitching struggles suggest a higher scoring game.

Team Trends

• The St. Louis Cardinals have a strong home record of 19-8 this season.
• The Baltimore Orioles are 15 games back in the AL East with a record of 19-35.
• In a recent game, the Cardinals had 14 hits and 2 home runs against the Orioles.
• Ryan O’Hearn of the Orioles hit a home run and had 3 RBIs in a game against the Cardinals.
• The Orioles’ pitcher Trevor Rogers allowed only 2 hits and no runs in a game against the Red Sox.

Cardinals vs Orioles Preview

The St. Louis Cardinals are set to visit the Baltimore Orioles at Oriole Park at Camden Yards. Fans can expect a night game on Wednesday, May 28, 2025, starting at 6:35 PM. The Cardinals will rely on Miles Mikolas, who has an ERA of 3.51 and a WHIP of 1.17, to lead their pitching efforts.

The Orioles will counter with Cade Povich on the mound. Povich enters the game with an ERA of 4.86 and a WHIP of 1.45. As the Cardinals and Orioles prepare to meet, both teams will aim to leverage their strengths to secure a win. The game promises to be an interesting matchup between these two teams.

Baltimore Orioles: Key Players and Stats

Gunnar Henderson leads the Orioles in several categories. He has a batting average of .261 and has hit 7 home runs. Henderson also ranks first in the league with 28 runs scored. Jackson Holliday is another important player for the Orioles. He has a batting average of .266 and has driven in 23 runs, which is the highest in the league. Holliday has hit 6 home runs this season. Adley Rutschman has played in 50 games this season. His batting average is .211, and he has 5 home runs. However, Rutschman is dealing with a head injury and may not play in the next game.

St. Louis Cardinals: Key Players and Stats

Brendan Donovan has been a key player for the Cardinals. His batting average is .328, making him one of the top hitters on the team. Donovan has scored 29 runs, but he is dealing with hip tightness and may not play. Willson Contreras is another important player for St. Louis. He has a batting average of .244 and leads the team with 29 RBIs. Contreras is also dealing with back spasms and might not be available for the game. Nolan Arenado has played in 50 games this season. He has a batting average of .238 and has hit 6 home runs. Arenado is expected to play despite a rib injury.

Final Betting Pick

The Cardinals have a solid chance to win with Miles Mikolas on the mound. His ERA of 3.51 is much lower than Cade Povich’s 4.86. The Cardinals also have a better overall record at 31-24 compared to the Orioles’ 19-35. This makes the Cardinals a good pick for the money line at +104.

For the over/under, choosing over 8.0 runs seems wise. Both teams have shown they can score, as seen in recent games. The Orioles’ pitching struggles, with a team ERA of 5.50, suggest more runs could be scored. This makes the over 8.0 a strong pick at -114.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.