St. Louis Cardinals vs Chicago White Sox MLB Betting Prediction

MLB St. Louis Cardinals vs Chicago White Sox Prediction 6/19

On Thursday, June 19, 2025, the St. Louis Cardinals will play against the Chicago White Sox at Rate Field in Chicago, IL. The game is set to start at 5:40 PM and will be broadcast on CHSN. Fans can expect a warm afternoon with a light breeze and light rain.

Cardinals vs. White Sox Betting Prediction

  • Money Line Prediction: St. Louis Cardinals -165. The Cardinals have a better overall record and recently won against the White Sox 12-2. Their road record is not strong, but they are facing a struggling White Sox team.
  • Over/Under Prediction: Over 8.0. Both teams have shown the ability to score runs, and the Cardinals put up 12 runs in their last game against the White Sox. The weather conditions may also favor more scoring.

Team Trends

  • The St. Louis Cardinals have a road record of 16-21 this season.
  • Chicago White Sox hold a home record of 16-19 this season.
  • The St. Louis Cardinals recently defeated the Chicago White Sox 12-2 on June 17th, 2025.
  • Chicago White Sox’s manager is Will Venable, while the Cardinals’ manager is Oliver Marmol.
  • The game on June 19, 2025, will be played at Rate Field in Chicago with a forecast of light rain.

Cardinals vs White Sox Preview

The St. Louis Cardinals will take on the Chicago White Sox at Rate Field on Thursday. The game starts at 5:40 PM, with fans tuning in on CHSN. The weather forecast predicts a warm afternoon with light rain and a gentle breeze.

Michael McGreevy will start for the Cardinals. He has an ERA of 3.09 and a WHIP of 0.86. On the other side, Mike Vasil will pitch for the White Sox. Vasil has an ERA of 1.99 and a WHIP of 1.28. Both pitchers will aim to lead their teams to a win.

Chicago White Sox: Key Players and Stats

The Chicago White Sox are seeing solid performances from their hitters. Miguel Vargas is leading the team with 10 home runs and 31 RBIs. His batting average is .242, and he plays third base.

Chase Meidroth and Lenyn Sosa are also contributing well. Meidroth has a batting average of .276 with 22 runs. Sosa is close with a .275 average and 17 RBIs.

Mike Vasil is the starting pitcher for the White Sox. His ERA is 1.99, and he has a win-loss record of 3-2. Vasil’s performance will be important in the upcoming game.

St. Louis Cardinals: Key Players and Performance

The St. Louis Cardinals have several players making an impact this season. Willson Contreras leads the team with 9 home runs and 45 RBIs. His batting average is .248, and he plays first base. Brendan Donovan is another standout for the Cardinals. He holds a batting average of .323 and has scored 38 runs. Donovan plays second base and has hit 4 home runs this season. Nolan Arenado adds depth to the lineup with a .244 batting average. He has hit 8 home runs and driven in 36 RBIs. Arenado plays third base and has participated in 68 games this season.

Final Betting Pick

The Cardinals are a strong pick for the money line at -165. They have a better overall record of 38-35 compared to the White Sox’s 23-50. Even though the Cardinals have a weaker road record, their recent 12-2 win against the White Sox shows they can perform well away from home.

For the over/under prediction, taking the over at 8.0 is reasonable. The Cardinals’ offense is capable of high-scoring games, as shown by their 12-run performance against the White Sox. Both teams have shown they can score, and the weather conditions might help increase the run totals in this game.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.