St. Louis Cardinals vs Cincinnati Reds MLB Betting Prediction

MLB St. Louis Cardinals vs Cincinnati Reds Prediction 4/28

The St. Louis Cardinals will play against the Cincinnati Reds on Monday, April 28, 2025. The game will take place at the Great American Ball Park. The first pitch is scheduled for 6:40 PM under the night sky.

Cardinals vs. Reds Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine 101. The Cardinals have a strong home record and good hitting stats, making them a solid value as underdogs.
  • Over/Under Prediction: Under 9.0 (-120). Both teams have shown solid pitching performances recently, suggesting a lower-scoring game.

Team Trends

  • The St. Louis Cardinals have a strong home record of 10-5 but struggle on the road with a record of 2-11.
  • Cincinnati Reds are performing better overall with a 15-13 record and are just 1 game back in the NL Central.
  • In their recent game against the Milwaukee Brewers, the Cardinals’ Erick Fedde pitched 5 2/3 innings but allowed 7 earned runs.
  • Cincinnati Reds’ Nick Lodolo had an impressive outing against the Colorado Rockies, allowing only 2 hits over 7 innings with 9 strikeouts.
  • Lars Nootbaar of the Cardinals has been consistent, contributing hits in multiple recent games.

Cardinals vs Reds Preview

The St. Louis Cardinals are set to visit the Cincinnati Reds at Great American Ball Park. This game is scheduled for Monday, April 28, 2025, and will begin at 6:40 PM. Both teams are looking to gain an edge in the NL Central division.

The Cardinals will rely on their starting pitcher to set the tone early. Meanwhile, the Reds will counter with their own starter, aiming to keep the Cardinals’ lineup in check. Fans can expect a competitive game under the night sky.

Cincinnati Reds: A Look at the Home Team’s Performance

The Cincinnati Reds have shown solid hitting this season. Elly De La Cruz leads the team with a .270 batting average. He also has 5 home runs, 20 runs, and 24 RBIs, ranking first in the league in these categories. TJ Friedl is another key player for the Reds. He has a .294 batting average and 15 runs, placing second in the league. Friedl’s contributions are vital for the team’s success this season. Gavin Lux adds depth to the lineup with a .333 batting average. He has 13 RBIs, which is third on the team. Lux’s performance helps the Reds maintain a competitive edge in their games.

St. Louis Cardinals: Key Players to Watch

Lars Nootbaar is a standout player for the St. Louis Cardinals. He leads the team with a .272 batting average. Nootbaar has hit 4 home runs and scored 18 runs, both ranking first in the league. Brendan Donovan is another important player for the Cardinals. He has a .359 batting average, which is impressive. However, Donovan is dealing with a rib injury and might not play in the upcoming games. Nolan Arenado also contributes significantly to the team. He has a .255 batting average and has hit 3 home runs. Arenado’s performance is crucial for the Cardinals’ success this season.

Final Betting Pick

The Cardinals are a strong pick for the MoneyLine at 101. Their home record stands at 10-5, showing they play well at home. Lars Nootbaar and Brendan Donovan have been key hitters, contributing to the team’s solid offensive stats.

The prediction for the game to go under 9.0 runs is based on recent pitching performances. Both teams have shown strong pitching, with the Reds having a 3.46 ERA and the Cardinals with 13 quality starts. This suggests a lower-scoring game is likely.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.