The St. Louis Cardinals will take on the Milwaukee Brewers on Saturday, September 13, 2025, at 8:15 PM. The game will be held at American Family Field in Milwaukee, WI. Fans can catch the action on FOX, as the Cardinals aim to end their four-game losing streak against the Brewers, who are leading the NL Central.

Cardinals vs. Brewers Betting Prediction

• Money Line Prediction: Milwaukee Brewers -166. The Brewers have a strong home record of 47-26 and are first in their division. The Cardinals are on a four-game losing streak and have a poor road record of 31-42.
• Over/Under Prediction: Under 7.5 (-102). Both starting pitchers have ERAs over 4.00, but the Brewers have a solid pitching staff with a team ERA of 3.62, which is second in the league. The Cardinals have struggled to score runs recently.

Team Trends

• Milwaukee Brewers have a strong home record this season with 47 wins and 26 losses.
• St. Louis Cardinals have struggled on the road with a record of 31 wins and 42 losses.
• The Cardinals have lost their last four games, including a recent 8-2 loss to the Brewers.
• Brewers’ Christian Yelich hit a home run in their last game against the Cardinals.
• The Brewers lead the NL Central Division, while the Cardinals are 18 games behind in the same division.

Cardinals vs Brewers Preview

The St. Louis Cardinals are set to take on the Milwaukee Brewers in a key NL Central game. The Cardinals have struggled recently, losing their last four games. They will look to Sonny Gray to help turn things around. Gray has a 4.45 ERA and a 13-8 record this season.

The Brewers, holding the top spot in the division, will counter with Jacob Misiorowski. Misiorowski has a 4.09 ERA and a 5-2 record. The game will be played at American Family Field, where the weather is expected to be warm with broken clouds. The retractable roof may limit the impact of the wind during the game.

Milwaukee Brewers: A Look at the Home Team

The Milwaukee Brewers have strong hitters this season. Brice Turang leads the team with a .289 batting average and 18 home runs. William Contreras is right behind with a .261 average and 17 home runs. In team hitting, the Brewers rank 3rd in batting average at .260. They are 2nd in on-base percentage with .332. Their slugging percentage is .408, placing them 9th. On the pitching side, Jacob Misiorowski will start for the Brewers. He holds an ERA of 4.09 and a WHIP of 1.09. His record stands at 5 wins and 2 losses.

St. Louis Cardinals: Analyzing the Visitors

The St. Louis Cardinals have some key hitters this season. Willson Contreras leads the team with 20 home runs and a .254 batting average. Alec Burleson follows with 17 home runs and a .283 average. Masyn Winn and Brendan Donovan have also contributed with their consistent performances. In terms of team hitting, the Cardinals rank 11th in batting average at .245. Their on-base percentage is .312, placing them 16th. The team’s slugging percentage is .378, ranking 20th. They have hit 138 home runs, ranking 22nd in the league. Sonny Gray will be the starting pitcher for the Cardinals. He has an ERA of 4.45 and a WHIP of 1.22. Gray’s record for the season is 13 wins and 8 losses. The Cardinals’ pitching staff ranks 21st in ERA with a value of 4.29.

Final Betting Pick

The Milwaukee Brewers are a strong pick on the money line at -166. Their home record of 47-26 shows they play well at American Family Field. The Brewers are first in their division, which adds to their advantage against the Cardinals. The Cardinals have struggled on the road with a 31-42 record and are currently on a four-game losing streak. This makes it a tough challenge for them to break the streak against a top team like the Brewers.

For the over/under prediction, the under 7.5 at -102 seems reasonable. Both starting pitchers have ERAs over 4.00, but the Brewers’ team ERA of 3.62 is second in the league. This suggests they can limit the Cardinals’ scoring. The Cardinals have also had trouble scoring runs recently, which supports the under pick. The Brewers’ solid pitching staff should keep the game low-scoring, making the under a strong choice.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.