On Saturday, October 4, 2025, the Clemson Tigers will travel to face the North Carolina Tar Heels at Kenan Stadium in Chapel Hill, NC. This game is part of Week 6 of the 2025 Regular Season and will kick off at 12:00 PM. Fans can catch the action live on ESPN.

Clemson vs. North Carolina Betting Prediction

• Money Line Prediction: Clemson Tigers -610. Clemson has a strong record after a loss, going 13-2 in their last 15 games. North Carolina has struggled at home this season with a 1-1 record.
• Over/Under Prediction: Under 45.5. Both teams have had low-scoring games this season, and their defenses are ranked similarly in points against.

Team Trends

• Clemson Tigers have a 0-1 record on the road this season.
• North Carolina Tar Heels have a 1-1 record at home this season.
• Clemson Tigers rank 11th in sacks with 10 this season.
• North Carolina Tar Heels rank 5th in interceptions with 4 this season.
• Both teams have allowed 91 points this season, ranking 59th in points against.

Clemson vs North Carolina Preview

The Clemson Tigers are heading into Week 6 with a 1-3 record. They have struggled on the road, losing their only away game so far. Their conference record stands at 0-2, placing them 13th out of 17 teams. Clemson is looking to break a two-game losing streak and improve their standing in the Atlantic Coast Conference.

The North Carolina Tar Heels have a 2-2 record this season. They are 1-1 at home and have not yet played a conference game. Currently, they are ranked 17th in their conference. The Tar Heels aim to bounce back from a recent loss and secure a win at Kenan Stadium.

North Carolina Tar Heels – Home Team Overview

The North Carolina Tar Heels are part of the Atlantic Coast Conference. They play their home games at Kenan Stadium. This season, their record stands at 2-2, with a home record of 1-1.

Quarterback Gio Lopez has played in all four games this season. He has thrown for 430 passing yards, ranking first on the team. Max Johnson, another quarterback, has played two games with 170 passing yards.

Running back Demon June leads the team with 250 rushing yards. He has one rushing touchdown and five receptions. The team has scored 84 points this season, and they rank 77th in points scored.

Clemson Tigers – Away Team Analysis

Clemson Tigers are part of the Atlantic Coast Conference. They have a 1-3 record this season, with no wins on the road. Their last game ended in a 34-21 loss to Syracuse.

Quarterback Cade Klubnik is leading with 996 passing yards this season. He has thrown six touchdowns and four interceptions. His fantasy points total is 67.8.

Running back Adam Randall has 338 rushing yards and three touchdowns. Bryant Wesco Jr. leads the receivers with 389 yards and five touchdowns. Clemson’s offense has scored 79 points, ranking 81st.

Final Betting Pick

The Clemson Tigers are favored with a money line of -610. This is because Clemson has a good record after a loss, winning 13 of their last 15 games. They also perform well in away games, with a 19-9 record over the last 28 away games. North Carolina has struggled at home this season, with a 1-1 record, making Clemson a strong pick.

The over/under is set at 45.5, with the prediction leaning towards the under. Both teams have had low-scoring games this season. Clemson’s defense is ranked 59th in points against, while North Carolina’s is the same. These rankings suggest a lower-scoring game, supporting the under 45.5 prediction.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.