The Illinois Fighting Illini will visit the Duke Blue Devils on Saturday, September 6, 2025. This game is part of Week 2 in the 2025 regular season. It will take place at Wallace Wade Stadium in Durham, NC, and fans can watch it on ESPN at 12:00 PM.

Illinois vs. Duke Betting Prediction

• Money Line Prediction: Duke +126. Duke has a strong home record and has shown good performance in their recent game. Illinois is ranked higher, but Duke’s home advantage and recent form make them a good value pick.
• Over/Under Prediction: Over 49.5. Both teams have strong offenses, with Illinois scoring 52 points and Duke scoring 45 in their last games. This suggests a high-scoring game, making the over a favorable choice.

Team Trends

• Illinois Fighting Illini are ranked #12 in both the AP and Coaches Polls.
• Duke Blue Devils won their last home game of the season, making their home record 1-0.
• Illinois Fighting Illini scored 52 points in their first game, ranking them 13th in points for.
• Duke Blue Devils have a strong passing offense, ranking 14th with 389 passing yards.
• Both Illinois and Duke have not allowed any interceptions this season, sharing the 1st rank in this category.

Illinois vs Duke Preview

The Illinois Fighting Illini are set to play against the Duke Blue Devils in Week 2 of the 2025 season. Both teams have a 1-0 record so far. Illinois is ranked 12th in both the AP and Coaches Polls. They are coming off a win in their last game and are looking to keep the momentum going.

Duke is also coming off a win. They are playing at home in Wallace Wade Stadium. The Blue Devils are unranked, but they are eager to show their strength against a ranked team. Fans can expect a competitive game as both teams aim to improve their season records.

Duke Blue Devils: Key Players and Projections

Darian Mensah is Duke’s top quarterback. He has played one game with 389 passing yards. He also has 3 passing touchdowns and 26.6 fantasy points.

Jaquez Moore leads the running backs with 44 rushing yards and 1 rushing touchdown. Peyton Jones also has a rushing touchdown with 28 rushing yards. Anderson Castle has the most rushing yards on the team with 69.

Sahmir Hagans leads the wide receivers with 54 receiving yards and 2 touchdowns. Que’Sean Brown has 93 receiving yards. Cooper Barkate has 117 receiving yards and 5 receptions.

Illinois Fighting Illini: A Strong Start

The Illinois Fighting Illini are ranked #12 in both the AP and Coaches Poll. They play in the Big Ten Conference and call Memorial Stadium in Champaign their home. This season, they have a 1-0 record with their win coming at home.

In their first game, quarterback Luke Altmyer led the team with 217 passing yards and 3 touchdowns. He earned 19.1 fantasy points in that game. Ethan Hampton also played but had only 14 passing yards and no touchdowns.

Running back Aidan Laughery had a strong game with 101 rushing yards and 2 touchdowns. Kaden Feagin added 74 rushing yards and 1 touchdown. Receiver Hank Beatty led with 108 receiving yards, while Justin Bowick had 23 yards and 2 touchdowns.

Final Betting Pick

Duke’s home record is strong, making them a solid pick for the money line at +126. They have a perfect record in home games this season, winning their last game with a score of 45 points. This shows their ability to perform well at Wallace Wade Stadium, giving them an edge over Illinois, despite Illinois’s higher ranking.

The over 49.5 is a favorable choice given both teams’ offensive strengths. Illinois scored 52 points in their last game, while Duke put up 45. Both teams have shown they can score, which suggests a high-scoring game is likely. This makes the over a reasonable bet for this matchup.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.