Illinois Fighting Illini vs Indiana Hoosiers NCAAF Betting Prediction
PublishedSeptember 16, 2025,            Posted By: Maria Uebelhor
Last updated:September 16, 2025 ,

NCAAF Illinois Fighting Illini vs Indiana Prediction 9/20

The Illinois Fighting Illini will take on the Indiana Hoosiers in Week 4 of the 2025 Regular Season. Both teams are undefeated with a 3-0 record. The game will be held at Memorial Stadium in Bloomington, IN, on Saturday, September 20, 2025, at 7:30 PM. Fans can catch the action on NBC.

Illinois vs. Indiana Betting Prediction

  • Money Line Prediction: Illinois Fighting Illini +163. Illinois has a strong start to the season with a 3-0 record. They have shown solid performance both at home and on the road.
  • Over/Under Prediction: Under 52.5 (-113). Both teams have strong defenses, with Illinois allowing only 22 points and Indiana 23 points so far this season.

Team Trends

  • Illinois Fighting Illini are ranked #9 in the AP Poll and #8 in the Coaches Poll.
  • Indiana Hoosiers are ranked #19 in the AP Poll and #17 in the Coaches Poll.
  • Illinois Fighting Illini have a perfect road record of 1-0 this season.
  • Indiana Hoosiers have won all three of their home games this season.
  • Illinois Fighting Illini’s defense is ranked 8th in points against, allowing only 22 points this season.

Illinois vs Indiana Preview

The Illinois Fighting Illini and Indiana Hoosiers are set for a key game in Week 4 of the 2025 season. Both teams have started strong with 3-0 records. Illinois is ranked #9 in the AP Poll and #8 in the Coaches Poll. Indiana is ranked #19 in the AP Poll and #17 in the Coaches Poll. This game is the first conference game for both teams in the Big Ten.

Illinois has a balanced record with wins at home and on the road. Indiana has been strong at home, winning all three games there. The game will be played at Memorial Stadium in Bloomington, IN, under the lights. Fans can watch the game on NBC at 7:30 PM on September 20, 2025.

Indiana Hoosiers: Strong Start at Home

The Indiana Hoosiers are ranked #19 in the AP poll and #17 in the Coaches Poll. They play in the Big Ten conference and their home games take place at Memorial Stadium in Bloomington, IN. This season, the Hoosiers are 3-0, with all wins coming at home.

Quarterback Fernando Mendoza has been impressive with 708 passing yards and 9 touchdowns in 3 games. Alberto Mendoza has also contributed with 139 passing yards and 3 touchdowns in 2 games. On the ground, Kaelon Black has rushed for 217 yards and 1 touchdown over 3 games.

In the receiving department, Omar Cooper Jr. leads with 299 receiving yards and 4 touchdowns. The Hoosiers’ offense ranks 5th in points scored with 156 and 2nd in rushing yards with 926. Defensively, they have allowed only 23 points, placing them 9th in that category.

Illinois Fighting Illini: Road Warriors

The Illinois Fighting Illini are ranked #9 in the AP poll and #8 in the Coaches Poll. They are part of the Big Ten conference and call Memorial Stadium in Champaign, IL, their home. This season, Illinois has a perfect 3-0 record, with one win on the road.

Quarterback Luke Altmyer leads the team with 709 passing yards and 8 touchdowns in 3 games. Running back Kaden Feagin has rushed for 222 yards and 3 touchdowns. Wide receiver Hank Beatty is a key player with 289 receiving yards and 1 touchdown over 3 games.

The Illini offense has scored 135 points, placing them 12th in the nation. They have gained 723 passing yards and 500 rushing yards. On defense, Illinois has allowed 22 points, ranking them 8th, and they have recorded 9 sacks.

Final Betting Pick

Illinois Fighting Illini have shown they can win both at home and on the road. Their 3-0 record includes a strong road win against Duke, where they scored 45 points. This shows they can perform well away from home, making the money line prediction of Illinois +163 a solid choice.

The over/under prediction of under 52.5 points is also reasonable. Both teams have strong defenses, with Illinois allowing only 22 points this season and Indiana allowing 23. With both teams ranked in the top 10 for points against, a lower-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.