The Michigan State Spartans will play against the USC Trojans on Saturday, September 20, 2025. This game is part of Week 4 of the 2025 Regular Season. It will take place at the Los Angeles Memorial Coliseum in Los Angeles, CA, and will be broadcast on FOX at 11:00 PM.

Michigan State vs. USC Betting Prediction

• Money Line Prediction: Michigan State Spartans +548. Michigan State has a strong start with a 3-0 record. They have shown they can score and compete in close games.
• Over/Under Prediction: Over 55.5. USC has scored a lot of points in their games, and Michigan State’s offense has been effective too. This could lead to a high-scoring game.

Team Trends

• USC Trojans are ranked #25 in the AP poll.
• Michigan State Spartans have not played an away game yet this season.
• USC Trojans have a perfect 2-0 home record this season.
• Michigan State Spartans have a strong defense with 6 sacks, ranking 8th.
• USC Trojans lead in sacks this season with 14, ranking 1st.

Michigan State vs USC Preview

The Michigan State Spartans are ready for their first road game of the season. They have a perfect 3-0 record, all of which were home games. This game will test their skills away from Spartan Stadium. The Spartans are not ranked in the AP poll, but they are looking to make a statement against a ranked team.

The USC Trojans also hold a 3-0 record and are ranked 25th in the AP poll. They have been strong at home, winning both games played at the Los Angeles Memorial Coliseum. The Trojans have already secured a conference win this season. This game offers them a chance to solidify their place in the Big Ten standings.

USC Trojans: A Look at the Team and Players

The USC Trojans are ranked #25 in the AP poll. They play in the Big Ten Conference. Their home games take place at the Los Angeles Memorial Coliseum.

USC is undefeated this season with a record of 3-0. At home, they are 2-0, while on the road they are 1-0. They also hold a 1-0 record in conference games.

Jayden Maiava is the leading quarterback with 989 passing yards and 6 touchdowns in three games. Waymond Jordan leads the running backs with 286 rushing yards and 3 touchdowns. Makai Lemon stands out among wide receivers with 311 receiving yards and 2 touchdowns in three games.

Michigan State Spartans: Road Warriors Ready to Compete

Michigan State Spartans are part of the Big Ten Conference, with all their home games held at Spartan Stadium in Michigan. This season, they have a perfect record of 3-0, with all victories coming at home. Though they have not played on the road yet, they are prepared for the challenge.

Aidan Chiles leads the Spartans at quarterback with 656 passing yards and 6 touchdowns across three games. He has shown skill in managing the offense effectively. Makhi Frazier, the top running back, has 206 rushing yards and 2 touchdowns, though he is currently listed as questionable due to an injury.

Nick Marsh is a standout wide receiver with 194 receiving yards and 3 touchdowns. Defensively, the Spartans have allowed 70 points in three games. They rank 8th in sacks with 6 and 3rd in interceptions with 2, showcasing their defensive strength.

Final Betting Pick

Michigan State has a strong start with a 3-0 record. They have shown they can score and compete in close games. Their offense has been effective, putting up 42 points against Boston College and 41 against Youngstown State. This shows they can keep up in high-scoring games.

USC has also been scoring a lot, with 165 points in three games. This includes a 73-point game against Missouri State. Their offense ranks 2nd in points for this season. With both teams scoring well, betting on the over 55.5 seems like a good choice. The high-scoring trend from both teams supports this prediction.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.