The Syracuse Orange will play against the Clemson Tigers on Saturday, September 20, 2025. This game is part of Week 4 of the 2025 regular season. It will take place at Memorial Stadium in Clemson, SC, and will be broadcast on ESPN at 12:00 PM.

Syracuse vs. Clemson Betting Prediction

• Money Line Prediction: Syracuse +549. Syracuse has a strong offense, ranking 3rd in passing yards. Clemson’s home record is 1-1, which shows they are not unbeatable at home.
• Over/Under Prediction: Under 55.5. Clemson’s games have not gone over this season, and their defense ranks 42nd in points against.

Team Trends

• Syracuse Orange have not played an away game yet this season.
• Clemson Tigers have a home record of 1-1 this season.
• Syracuse has scored 119 points this season, ranking 21st in the nation.
• Clemson’s defense has recorded 6 sacks, ranking 8th in the nation.
• Syracuse won their last postseason game against Washington State, 52-35.

Syracuse vs Clemson Preview

The Syracuse Orange will travel to face the Clemson Tigers in an Atlantic Coast Conference game. Syracuse enters the game with a 2-1 record, riding a two-game win streak. They have not played on the road this season, making this their first away game. Syracuse’s last postseason game was a win against Washington State in the DirecTV Holiday Bowl.

Clemson has a 1-2 record, with a 1-1 mark at home. They are looking to bounce back from a loss. Clemson’s last postseason game was a loss to Texas in the College Football Playoff First Round. Both teams are unranked in the AP and Coaches polls. This game will be an important test for both teams in the conference standings.

Inside the Clemson Tigers

The Clemson Tigers play in the Atlantic Coast Conference. They call Memorial Stadium in Clemson, South Carolina, their home. This season, they have a record of 1-2 overall, with a 1-1 record at home.

Cade Klubnik leads the team at quarterback with 633 passing yards over three games. Adam Randall stands out as the top running back with 208 rushing yards. Bryant Wesco Jr. shines at wide receiver, amassing 310 receiving yards in three games.

This season, the Tigers have scored 58 points, ranking 66th in the nation. Their defense has given up 57 points, ranking 42nd. The team has a 2-1 record against the spread but has not hit the over in any of their games so far.

Spotlight on Syracuse Orange

The Syracuse Orange play in the Atlantic Coast Conference. They have a regular season record of 2-1, all of which are home games. Their home stadium is the JMA Wireless Dome.

Steve Angeli is the leading quarterback for Syracuse. He has thrown for 1,108 yards and 8 touchdowns in three games. This places him 1st in passing yards and passing touchdowns in the league.

Yasin Willis has rushed for 139 yards and 4 touchdowns in two games. Darrell Gill Jr. leads the wide receivers with 269 receiving yards and 2 touchdowns. Syracuse ranks 21st in the nation for total points scored with 119 points this season.

Final Betting Pick

Syracuse’s money line at +549 offers value due to their strong passing game, ranked 3rd in the nation. They have shown they can score, putting up 66 points against Colgate. Their offense can challenge Clemson’s defense, especially since Clemson has already lost at home this season.

The under 55.5 is a solid pick as Clemson’s games have not exceeded this total. Their defense ranks 42nd in points against, keeping games low-scoring. With Syracuse’s road record yet to be tested, the under is a safer choice given Clemson’s defensive strength at home.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.