The Wyoming Cowboys will take on the Colorado Buffaloes in Week 4 of the 2025 regular season. The game is set for Saturday, September 20, 2025, at 10:15 PM. It will be played at Folsom Field in Boulder, CO, and will air on ESPN.

Wyoming vs. Colorado Betting Prediction

• Money Line Prediction: Wyoming Cowboys +374. Wyoming has a strong road record this season, winning their only away game. Colorado has struggled in night games, losing both they have played.
• Over/Under Prediction: Under 44.5 (-114). Wyoming games have all gone under this season, and Colorado’s home games have also stayed under.

Team Trends

• The Wyoming Cowboys have a perfect 1-0 record on the road this season.
• Colorado Buffaloes have a 1-1 record at home this season.
• Wyoming Cowboys’ defense is ranked 24th in points against, allowing 38 points this season.
• Colorado Buffaloes’ offense ranks 57th in points for, scoring 71 points this season.
• Wyoming Cowboys defeated the Akron Zips 10-0 in their only road game this season.

Wyoming vs Colorado Preview

The Wyoming Cowboys are heading into Week 4 with a 2-1 record. They have shown strength on the road, winning their only away game so far. The Cowboys are currently ranked 7th in their conference. They aim to bounce back after a recent loss and improve their standing in the Mountain West.

The Colorado Buffaloes hold a 1-2 record this season. They are 1-1 at home, showing mixed results at Folsom Field. The Buffaloes are ranked 4th in the Big 12 conference. They are looking to recover from their last defeat and climb up the standings. This game against Wyoming is a chance for both teams to reset their paths this season.

Buffaloes’ Key Players and Stats

The Colorado Buffaloes have a home record of 1-1 this season. Quarterbacks Kaidon Salter and Ryan Staub have played two games each. Salter has 261 passing yards and 33.2 fantasy points, while Staub leads with 361 passing yards and 3 touchdowns.

In the rushing department, DeKalon Taylor and Simeon Price have made contributions over three games. Taylor has 61 rushing yards and 10 receptions, while Price has 136 rushing yards. Price also stands out with one rushing touchdown and 20.5 fantasy points.

Wide receivers Sincere Brown and Joseph Williams have made impacts too. Brown has 135 receiving yards over two games, and Williams has 117 yards in three games. Both have achieved one receiving touchdown, helping the Buffaloes in their current 1-2 season record.

Wyoming Cowboys Ready to Compete

The Wyoming Cowboys have shown a strong start this season with a 2-1 record. They hold a perfect road record of 1-0. In the Mountain West Conference, they have yet to play a conference game.

Kaden Anderson is a standout quarterback for the Cowboys, playing in three games. He has thrown for 535 yards and 3 touchdowns. Anderson’s efforts have contributed to his 25.5 fantasy points.

Running back Sam Scott leads the team with 203 rushing yards and 1 touchdown across three games. Wide receiver Chris Durr has been effective with 284 receiving yards and 2 touchdowns. Erik Sandvik, the kicker, has made 2 field goals and 5 extra points in two games.

Final Betting Pick

Wyoming Cowboys have a solid road record, winning their only away game this season. Their defense ranks high in points against, sacks, and interceptions. This strong defense could help them secure a win against Colorado, especially considering Colorado’s struggles in night games.

The under 44.5 prediction is supported by both teams’ recent performances. Wyoming’s games have all stayed under this season. Colorado’s home games have also not exceeded the total, making the under a reasonable choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.