The Kansas City Chiefs will face off against the San Francisco 49ers at 4:25 ET on Sunday, October 20th. This matchup is being played at Levi’s Stadium in Santa Clara.

The 49ers are favored at -121 on the money line as they host the Chiefs at 4:25 ET on Sunday, October 20th at Levi’s Stadium in Santa Clara, CA. The Chiefs are +101 on the money line, and the point spread is very close, with the 49ers at -1.5. This week seven non-conference matchup is being televised on FOX, and the over/under line is set at 46.5 points.

• Date: Sunday, October 20th
• Time: 4:25 ET
• Location: Levi’s Stadium, Santa Clara
• TV: FOX

Chiefs vs 49ers

The Chiefs head into week 7 with a perfect 5-0 record, including a 17-10 win over the Chargers in week 4 and a 26-13 victory over the Saints in week 5. Kansas City was favored by 5 points against New Orleans and covered the spread, but the game’s 39 points fell short of the 43-point line. This was their third straight under. The Chiefs are 2-3 O/U this season.

Our power rankings have the Chiefs 3rd, and they have a 99.2% chance of making the playoffs and a 93.7% chance of winning the AFC West. They are 3-1-1 ATS and have been favored in all of their games, with an average scoring margin of +6.6.

Heading into week 7, the 49ers sit at 3-3, which is good enough to put them in first place in the NFC West. After a disappointing home loss to the Cardinals in week 5, San Francisco bounced back with a 36-24 win over the Seahawks in week 6. The 49ers were 3.5-point favorites in that game and covered the spread, improving their ATS record to 3-3. They have been favored in all of their games so far this season.

According to our projections, the 49ers have a 62.7% chance of making the playoffs and a 57.5% chance of winning the NFC West. They currently rank 4th in our NFL power rankings. Their average scoring margin this season is +5.3, and their O/U record is 4-2, with their games averaging 48.7 points.

Chiefs Injury Report

• Baylor Cupp – Undisclosed (Out)
• BJ Thompson – Chest (Out)
• Rashee Rice – Knee (Out)
• Charles Omenihu – Knee (Out)
• Isiah Pacheco – Ankle (Out)
• Clyde Edwards-Helaire – Illness (Questionable)
• Marquise Brown – Shoulder (Out)

49ers Injury Report

• Drake Jackson – Knee (Out)
• Jordan Mason – Shoulder (Questionable)
• Curtis Robinson – Knee (Out)
• Ambry Thomas – Forearm (Out)
• Talanoa Hufanga – Wrist (Out)
• Matthew Wright – Shoulder (Questionable)
• Demetrius Flannigan-Fowles – Calf (Questionable)
• Yetur Gross-Matos – Knee (Out)
• Elijah Mitchell – Hamstring (Out)
• Jordan Elliott – Knee (Questionable)
• Charvarius Ward – Knee (Questionable)
• Dre Greenlaw – Achilles (Out)
• Javon Hargrave – Triceps (Out)
• Christian McCaffrey – Calf/achilles (Out)
• Jon Feliciano – Knee (Out)
• Jake Moody – Right Ankle (Doubtful)
• Ricky Pearsall – Back (Questionable)
• Malik Mustapha – Ankle (Questionable)

Chiefs Offense Breakdown

Heading into week 7, the Chiefs sit 8th in our offensive power rankings. They are averaging 23.6 points per game, which ranks 13th in the NFL, and they are 11th in total yards per game with 354.6. Kansas City ranks 14th in passing attempts per game and 9th in passing yards, averaging 236.8 per game. On the ground, they are 8th in rushing attempts and 16th in rushing yards per game. The Chiefs rank 8th in 3rd-down conversion percentage and are converting 50% of their red zone opportunities, which also ranks 8th in the league.

Patrick Mahomes threw for 331 yards in week 5, completing 28 of 39 passes, but he did not throw a touchdown and had one interception. JuJu Smith-Schuster led the team with 130 receiving yards on 7 catches, while Kareem Hunt rushed for 102 yards and a touchdown on 27 carries. Kansas City scored 10 points in the 4th quarter against the Saints after being shut out in the 3rd quarter.

49ers Offense Breakdown

We have the 49ers ranked 6th in our offensive power rankings heading into week 7. They are 7th in the NFL in scoring, averaging 27 points per game. San Francisco has been strong on the ground, ranking 4th in rushing attempts and 3rd in rushing yards per game with 158. They also rank 5th in 3rd-down conversions, converting 45.7% of their attempts. However, they have struggled in the red zone, ranking 23rd in conversion percentage despite leading the NFL in red zone attempts.

In week 6, Brock Purdy threw for 255 yards and 3 touchdowns, finishing with a passer rating of 129. Deebo Samuel Sr. led the team with 102 receiving yards on 3 catches, while Isaac Guerendo had 10 carries for 99 yards. The 49ers scored 13 points in both the 2nd and 4th quarters against the Seahawks.

Chiefs Team Defense

In their 26-13 win over the Saints, the Chiefs’ defense allowed just 46 rushing yards on 15 attempts. They limited New Orleans to 220 total yards and 13 points, with one interception and one sack. The Chiefs gave up two passing touchdowns and allowed the Saints to complete 57.1% of their passes, with a 40% third-down conversion rate.

The Chiefs’ defense pressured the quarterback, leading in QB hits by a margin of +3, despite losing the tackles for loss battle. The Saints managed only 5.0 yards per attempt in the passing game.

49ers Team Defense

San Francisco’s defense came up with two interceptions and held the Seahawks to just 2.6 yards per attempt on the ground in their 36-24 win over Seattle. The 49ers’ secondary allowed just 5.9 yards per attempt and limited the Seahawks to 306 passing yards. Despite giving up 358 total yards, the 49ers’ defense made key plays, forcing two turnovers and holding Seattle to a 43.8% conversion rate on third down.

The 49ers’ defense also recorded one sack and won the quarterback hit battle by one. Even though they allowed 30 completions, Seattle only managed to score one passing touchdown, as San Francisco’s defense tightened up in key situations.

Chiefs vs 49ers Trends

• In their last ten games away from home, the Chiefs have a straight up record of 8-2 while going 6-2-2 vs. the spread. The team averaged 20 points per game in this stretch.
• Across their ten previous home games, San Francisco has an ATS mark of 6-4. Their straight up record in these matchups was 6-4 while averaging 29 points per game.
• The Chiefs have played well in their last three games as the betting underdog, going 3-0 straight up and 3-0 against the spread.
• San Francisco has done well both straight up and vs the spread when favored to win the game, going 2-1 SU and 2-1 ATS in their last three games.

Chiefs vs 49ers Prediction

For this week seven matchup between the Chiefs and 49ers, our pick is to take the Chiefs to cover as road underdogs. The point spread has the 49ers at -1.5, and although we have the Chiefs losing 23-22, we have them covering the spread.

As for an over/under pick, we like the under, with a projected combined score of 45 points and the O/U line sitting at 46.5 points.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.