The San Francisco 49ers will face off against the Arizona Cardinals at 4:25 ET on Sunday, January 5th. This matchup is being played at State Farm Stadium in Glendale.

FOX will broadcast the week 18 matchup between the 49ers and Cardinals, which is set to kick off at 4:25 ET at State Farm Stadium in Glendale, AZ. The Cardinals are favored at -207 on the money line and -4 on the point spread. The over/under line is at 42.5 points. The 49ers’ money line odds are +173. The 49ers and Cardinals both need to add their records.

• Date: Sunday, January 5th
• Time: 4:25 ET
• Location: State Farm Stadium, Glendale
• TV: FOX

49ers vs Cardinals

Heading into week 18, the 49ers rank 8th in our NFL power rankings despite their 6-10 record and 3-game losing streak. San Francisco’s playoff chances are now at 0.0%, and they sit 4th in the NFC West with a 1-4 division record. The 49ers are 4-5 at home and 2-5 on the road this season.

Against the spread, the 49ers are 5-11, with an average scoring margin of -1.5 points per game. They have failed to cover in three straight games. Their O/U record is 9-7, with the over hitting in two consecutive games.

Heading into week 18, the Cardinals sit 15th in our power rankings with a 7-9 record. They’ve lost two straight, including a 36-30 defeat to the Panthers in week 16 and a 13-9 loss to the Rams in week 17. Arizona was a 6.5-point underdog against LA but managed to cover the spread despite the loss. The O/U line was 48 points, and the teams combined for just 22.

Arizona’s playoff chances are now at 0.0%, but they have a +0.1 scoring margin and are 10-6 against the spread. They’ve gone 7-2 as underdogs and 2-4 as favorites. Their O/U record is 7-8-1, with their games averaging 44.2 points compared to a 46.8-point line.

49ers Injury Report

• Brandon Allen – Gameday Inactive (Out)
• Javon Hargrave – Triceps (Out)
• De’Vondre Campbell Sr. – Suspension (Out)
• Christian McCaffrey – Knee (Out)
• Trent Williams – Ankle (Out)
• Jon Feliciano – Knee (Out)
• Charvarius Ward – Personal (Out)
• George Odum – Knee (Out)
• Kevin Givens – Pectoral (Out)
• Dre Greenlaw – Calf (Out)
• Mitch Wishnowsky – Back (Out)
• Ben Bartch – Ankle (Out)
• Colton McKivitz – Knee (Probable)
• Khalil Davis – Gameday Inactive (Out)
• Brandon Aiyuk – Knee (Out)
• Drake Jackson – Knee (Out)
• Brock Purdy – Right Elbow (Questionable)
• Curtis Robinson – Knee (Out)
• Jaylon Moore – Quadriceps (Out)
• Elijah Mitchell – Hamstring (Out)
• Aaron Banks – Knee (Out)
• Jordan Mason – Ankle (Out)
• Spencer Burford – Calf (Out)
• Robert Beal Jr. – Ankle (Out)
• Israel Abanikanda – Gameday Inactive (Out)
• Ji’Ayir Brown – Ankle (Probable)
• Darrell Luter Jr. – Pelvis (Out)
• Mason Pline – Undisclosed (Out)

Cardinals Injury Report

• Matt Prater – Left Knee (Questionable)
• Angelo Blackson – Undisclosed (Out)
• James Conner – Knee (Out)
• Will Hernandez – Knee (Out)
• Justin Jones – Triceps (Out)
• Bilal Nichols – Stinger (Out)
• Dennis Gardeck – Knee (Out)
• Jonah Williams – Knee (Out)
• Carter O’Donnell – Undisclosed (Out)
• Blake Gillikin – Right Foot (Out)
• Jesse Luketa – Thigh (Out)
• Joey Blount – Ribs (Out)
• BJ Ojulari – Knee (Out)
• Garrett Williams – Head (Questionable)
• Paris Johnson Jr. – Knee (Out)
• Trey Benson – Ankle (Out)
• Emari Demercado – Back (Out)
• Elijah Jones – Heel (Out)

49ers Offense Breakdown

San Francisco heads into week 18 ranked 12th in our offensive power rankings, averaging 22.8 points per game, which ranks 13th in the NFL. They are 5th in the league in total yards per game (372.6) and 4th in passing yards per game (246), despite ranking 24th in passing attempts. On the ground, they average 126.6 rushing yards per game, ranking 11th in the NFL, on 26.8 attempts per game. The 49ers rank 9th in 3rd-down conversions, with a 42.9% success rate, and are 7th in red zone attempts, but they have struggled to convert, ranking 23rd in the league with a 14.8% conversion rate.

Brock Purdy threw for 377 yards and 3 touchdowns in week 17, completing 27 of 35 passes, but he also had 2 interceptions. Ricky Pearsall led the team with 8 catches for 141 yards and a touchdown, while Isaac Guerendo had 34 rushing yards on 9 carries. San Francisco scored on all 5 of their red zone trips and converted 62.5% of their 3rd-down attempts in the loss to Detroit.

Cardinals Offense Breakdown

Heading into week 18, the Cardinals rank 14th in our offensive power rankings. They are 15th in the NFL in scoring, averaging 22.1 points per game, and 11th in total offense, with 356.1 yards per game. Arizona has leaned on their run game, ranking 7th in rushing yards per game, with 143.8, on 27.2 attempts per contest. They have been strong on 3rd down, converting 43.4% of their attempts, which ranks 7th in the league, but they are 19th in red zone efficiency.

In week 17, Kyler Murray threw for 321 yards on 33/48 passing, with 1 touchdown and 2 interceptions. He was sacked 4 times. Trey McBride led the team with 12 catches for 123 yards, and Michael Carter had 70 rushing yards on 13 carries. Arizona struggled to score against the Rams, putting up just 9 points, all in the second half.

49ers Team Defense

In their 40-34 loss to the Lions, the 49ers’ defense allowed 287 passing yards and 152 rushing yards on 33 attempts. The unit struggled to get off the field, as the Lions converted 64.3% of their third down attempts. Overall, the 49ers gave up 439 total yards and allowed Detroit to complete 76.5% of their passes.

San Francisco’s defense did manage two sacks in the game and had five more tackles for loss than the Lions. However, the 49ers also allowed three passing touchdowns and gave up big plays, as the Lions averaged 8.4 yards per passing attempt.

Cardinals Team Defense

In their most recent game, the Cardinals’ defense gave up just 189 passing yards and held the Rams to 13 points, but they still lost 13-9. They struggled to generate pressure, failing to record any sacks and losing the quarterback hit differential by -4. The Cardinals defended the run well, allowing just 68 yards on 22 attempts, and the Rams converted 40% of their third down attempts against Arizona.

Despite their defensive efforts, the Cardinals’ offense couldn’t get much going, putting even more pressure on the defense. Arizona’s defense limited the Rams to 5.9 yards per attempt in the passing game and kept them out of the end zone, but it wasn’t enough to secure the win.

49ers vs Cardinals Trends

• In their last five games away from home, the 49ers have a straight up record of 2-3 while going 1-4 vs. the spread. The team averaged 19 points per game in this stretch.
• Through their last ten home contests, the Cardinals offense has averaged 21 points per game while allowing an average of 26. Arizona posted an overall record of 3-7 while going 6-4 ATS.
• Going back to their last ten games as the underdog, the 49ers have a straight up record of 4-6. But, their mark vs the spread was just 5-5.
• Going back to their last five games as the favorite, the Cardinals have a straight up record of 2-3. But, their mark vs the spread was just 2-3.

49ers vs Cardinals Prediction

Our pick vs. the spread in this week 18 matchup between the 49ers and Cardinals is to take the 49ers to cover as road underdogs. The point spread currently has the 49ers at +4, and although we have the Cardinals pulling off the upset by a score of 19-17, the 49ers’ pick to cover is based on the point spread.

As for the over/under, with the line sitting at 42.5 points, our recommendation is to take the under, with a projected combined score of 36 points.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.