The San Francisco 49ers will face off against the Seattle Seahawks at 8:15 ET on Thursday, October 10th. This matchup is being played at Lumen Field in Seattle.

The 49ers are favored on the road with money line odds of -180 as they take on the Seahawks in a week six NFC West matchup. The game, being played at Lumen Field in Seattle, is set for 8:15 ET on Thursday, October 10th. The Seahawks, the underdog, have money line odds of +152 and a +3.5 point spread. The over/under line is at 47.5 points, and the game is being televised by AMZN.

• Date: Thursday, October 10th
• Time: 8:15 ET
• Location: Lumen Field, Seattle
• TV: AMZN

49ers vs Seahawks

After bouncing back from two straight losses with a week 4 win over the Patriots, the 49ers couldn’t keep the momentum going, falling to the Cardinals 24-23 in week 5. San Francisco came into the game as 7-point favorites but couldn’t get it done at home, dropping their record to 2-3. They are now 0-2 in division play and 0-2 on the road, but they have a +4 scoring margin and rank 4th in our NFL power rankings.

Despite their losing record, the 49ers still have a 50.7% chance of making the playoffs and a 41.8% chance of winning the NFC West. They are 2-3 against the spread, having been favored in all of their games so far. Their O/U record is 3-2, with their games averaging 46.4 points (the O/U line has averaged 45.1).

Seattle heads into week 6 against the 49ers looking to snap a two-game losing streak, which includes a 29-20 home loss to the Giants in week 5. The Seahawks were 7-point favorites in that game but couldn’t get the win, dropping their record to 3-2. Despite the loss, they remain in first place in the NFC West, though they are 0-2 in conference play.

Our projections give Seattle a 28.1% chance of making the playoffs and a 21.6% chance of winning the division. They rank 23rd in our NFL power rankings. The over has hit in each of their last two games, and their O/U record is 4-1 this season. Their games have averaged 47.2 points, with an average line of 42.4.

49ers Injury Report

• Demetrius Flannigan-Fowles – Calf (Questionable)
• Yetur Gross-Matos – Knee (Out)
• Elijah Mitchell – Hamstring (Out)
• Jordan Elliott – Knee (Questionable)
• Drake Jackson – Knee (Out)
• Ambry Thomas – Forearm (Out)
• Curtis Robinson – Knee (Out)
• Talanoa Hufanga – Wrist (Questionable)
• Dre Greenlaw – Achilles (Out)
• Charvarius Ward – Knee (Questionable)
• George Kittle – Ribs (Questionable)
• Fred Warner – Ankle (Questionable)
• Jon Feliciano – Knee (Out)
• Chris Conley – Oblique (Questionable)
• Javon Hargrave – Triceps (Out)
• Christian McCaffrey – Calf/achilles (Out)
• Jake Moody – Right Ankle (Doubtful)
• Ji’Ayir Brown – Ankle (Questionable)
• Jacob Cowing – Shoulder (Probable)
• Ricky Pearsall – Back (Out)

Seahawks Injury Report

• Byron Murphy II – Hamstring (Questionable)
• Brady Russell – Shoulder (Probable)
• Jerrick Reed II – Undisclosed (Out)
• Derick Hall – Foot (Questionable)
• Cameron Young – Knee (Questionable)
• Joshua Onujiogu – Undisclosed (Out)
• Rayshawn Jenkins – Hand (Questionable)
• George Fant – Knee (Out)
• Leonard Williams – Ribs (Probable)
• Johnathan Hankins – Hand (Probable)
• Uchenna Nwosu – Thigh (Out)
• Pharaoh Brown – Groin (Questionable)
• Noah Fant – Toe (Probable)
• DK Metcalf – Hand (Probable)
• Julian Love – Hamstring (Questionable)
• Boye Mafe – Knee (Questionable)
• Abraham Lucas – Knee (Out)
• Riq Woolen – Ankle (Questionable)
• George Holani – Ankle (Out)
• Laviska Shenault Jr. – Shin (Probable)
• Marcus Simms – Undisclosed (Out)

49ers Offense Breakdown

Heading into week 6, the 49ers are 9th in the NFL in points per game, averaging 25.2, and they rank 2nd in yards per game with 407.4. They are 16th in passing attempts but 4th in passing yards, averaging 263.4 per game. On the ground, they rank 6th in rushing attempts and 7th in rushing yards, with 144 per game. San Francisco is 5th in the NFL in 3rd-down conversion rate at 46.6% and ranks 22nd in red zone conversion percentage.

In week 5, the 49ers scored all 23 of their points in the first half against the Cardinals. Brock Purdy threw for 244 yards on 19/35 passing, with one touchdown and two interceptions. Jordan Mason led the team in rushing with 89 yards on 14 carries, while Brandon Aiyuk had 8 receptions for 147 yards. Before Aiyuk’s performance, Jauan Jennings had an 88-yard game in week 4 and an 11-catch, 175-yard, 3-touchdown game in week 3.

Seahawks Offense Breakdown

Heading into week 6, Seattle ranks 20th in our offensive power rankings. They lead the NFL in passing attempts per game (39.8) and are 3rd in passing yards, averaging 270.8 per game. Geno Smith threw for 284 yards (28/40) and a touchdown in week 5, after his 395-yard performance in week 4. DK Metcalf had 104 receiving yards in week 4, but Tyler Lockett led the team in week 5 with 75 yards on 4 catches.

On the ground, Seattle ranks 28th in rushing attempts and 22nd in rushing yards, with 105.4 per game. Smith led the team in week 5 with 72 rushing yards on 4 carries. Seattle is 16th in 3rd-down conversions, with a 37.3% success rate, but they struggled in week 5, converting just 3 of 11 attempts.

49ers Team Defense

In their 24-23 loss to the Cardinals, the 49ers’ defense gave up 189 passing yards on 19 completions. They did force one interception and held Arizona to a 63.3% completion rate. However, the 49ers struggled against the run, allowing 169 yards on just 26 attempts, with Arizona averaging 6.5 yards per attempt. On third downs, the 49ers allowed the Cardinals to convert 30% of their chances.

The 49ers’ defense managed only one sack in the game and had a negative quarterback hit differential of -3. Despite their struggles against the run, they did a good job defending the pass, holding the Cardinals to just one passing touchdown.

Seahawks Team Defense

In their 29-20 loss to the Giants, the Seahawks’ defense allowed 420 yards and 175 rushing yards on 34 attempts. They gave up two passing touchdowns and allowed the Giants to convert on 43.8% of their third down attempts. Seattle’s defense did manage to sack the quarterback three times.

The Giants completed 67.6% of their passes for 245 yards, averaging 7.2 yards per attempt. Additionally, the Seahawks had a -4 differential in tackles for loss, contributing to their struggles against the run.

49ers vs Seahawks Trends

• Across their five previous road games, San Francisco has an ATS mark of 2-3. Their straight up record in these matchups was 2-3 while averaging 27 points per game.
• Across their three previous home games, Seattle has an ATS mark of 0-2-1. Their straight up record in these matchups was 2-1 while averaging 24 points per game.
• Going back to their previous ten games as the underdog, Seattle has an ATS mark of 5-5 while going 2-8 straight up.
• As the betting favorite, the 49ers have an ATS mark of just 2-3 in their last five games. San Francisco posted a straight up mark of 2-3 in these matchups.

49ers vs Seahawks Prediction

For this week six matchup between the 49ers and Seahawks, we have the 49ers coming out on top by a score of 29-24. With the point spread sitting at -3.5 in favor of the 49ers, our pick is to take the 49ers to cover as road favorites.

As for the over/under, with the line at 47.5 points, we like the over, projecting a combined score of 53 points. This could be a good opportunity to take the over before the line moves.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.