Indianapolis Colts vs Los Angeles Rams NFL Betting Prediction
PublishedSeptember 24, 2025,            Posted By: Maria Uebelhor
Last updated:September 24, 2025 ,

NFL Indianapolis Colts vs Los Angeles Rams Prediction 9/28

The Indianapolis Colts will play the Los Angeles Rams on Sunday, September 28, 2025. The game will take place at SoFi Stadium in Inglewood, California. Fans can watch the action on FOX at 4:05 PM. The Colts come in with a perfect 3-0 record, while the Rams hold a 2-1 record this season. Both teams will look to continue their strong starts in this Week 4 game.

Colts vs. Rams Betting Prediction

  • Money Line Prediction: Colts +156. The Colts have a strong start this season with a 3-0 record. They also won their only road game so far, making them a good value pick.
  • Over/Under Prediction: Over 49.5. Both teams have shown they can score, with the Colts scoring 29 or more in each game and the Rams scoring 26 or more in two games.

Team Trends

  • The Indianapolis Colts have a perfect start to the season with a 3-0-0 record.
  • The Los Angeles Rams hold a 2-1-0 record this season, with a win at home.
  • The Colts won their recent away game against the Tennessee Titans with a score of 41-20.
  • The Rams lost their last away game to the Philadelphia Eagles, 33-26.
  • This game will be played at SoFi Stadium, which is a dome, minimizing weather impact.

Colts vs Rams Preview

The Indianapolis Colts are off to a strong start this season. They have a 3-0 record and lead the AFC South. Daniel Jones, their quarterback, is expected to pass for over 200 yards. Jonathan Taylor is another key player, with nearly 92 rushing yards projected for this game.

The Los Angeles Rams have a 2-1 record and rank fourth in the NFC West. Matthew Stafford will aim to lead his team with a projected 254 passing yards. Puka Nacua and Davante Adams are the top targets, expected to combine for over 160 receiving yards. This game at SoFi Stadium will be a test for both teams as they try to maintain their positions in their divisions.

Los Angeles Rams Gear Up for Upcoming Game

The Los Angeles Rams have a strong start to the season with a 2-1-0 record. At SoFi Stadium, they hold a 1-0-0 record. Sean McVay leads the team as the head coach, and they play in the NFC West division.

Matthew Stafford is the top quarterback for the Rams, with a projected 254.5 passing yards and 1.6 touchdowns for the upcoming game. Running back Kyren Williams has a projection of 73.5 rushing yards and 0.8 touchdowns. Wide receiver Puka Nacua is expected to make an impact with 92.9 receiving yards and 0.4 touchdowns.

In the previous regular season, the Rams scored 367 points, ranking 19th. Their defense allowed 386 points, placing them 16th. The team is dealing with injuries, including Ahkello Witherspoon and Keir Thomas on injured reserve, while Steve Avila and Nick Hampton are questionable for Week 4.

Indianapolis Colts Ready for Battle on the Road

The Indianapolis Colts have an impressive start with a 3-0-0 record this season. Head coach Shane Steichen guides the team from the sidelines. Their division is the AFC South, and they have a perfect road record of 1-0-0.

Quarterback Daniel Jones leads the Colts with a projection of 216.7 passing yards and 1.1 touchdowns. Running back Jonathan Taylor is set to contribute with 91.8 rushing yards and 0.7 touchdowns. Wide receiver Michael Pittman Jr. is expected to gain 55.7 receiving yards with 0.3 touchdowns.

Last season, the Colts scored 377 points, putting them 16th in the league. On defense, they allowed 427 points, ranking them 23rd. Injuries are a concern, with Alec Pierce questionable and several players on injured reserve, including Kenny Moore II and D.J. Montgomery.

Final Betting Pick

The Colts are a strong pick for the money line at +156. They have started the season with a 3-0 record, showing they can win both at home and on the road. Their recent win against the Titans, 41-20, highlights their ability to perform well away from home.

The over/under prediction of over 49.5 is supported by both teams’ scoring abilities. The Colts have scored 29 or more in each game, while the Rams have put up 26 or more in two games. Both offenses have shown they can move the ball effectively, which should lead to a high-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.