The Indianapolis Colts will play against the Tennessee Titans on Sunday, September 21, 2025. The game will be held at Nissan Stadium in Nashville, TN. Kickoff is set for 1:00 PM and will be broadcast on CBS. The Colts are currently 2-0, while the Titans are looking for their first win of the season.

Colts vs. Titans Betting Prediction

• Money Line Prediction: Colts -195. The Colts have a strong start this season with a 2-0 record. The Titans have struggled at home, losing their only home game so far.
• Over/Under Prediction: Over 43.5. Both teams have shown the ability to score, with the Colts scoring over 29 points in their last two games and the Titans allowing 33 points in their last home game.

Team Trends

• The Indianapolis Colts are off to a strong start this season with a 2-0 record.
• The Tennessee Titans have struggled with a 0-2 record this season.
• In their recent home game, the Titans lost to the Los Angeles Rams 33-19.
• The Colts won their last game against the Denver Broncos 29-28 at home.
• The game will be held at Nissan Stadium in Nashville, TN, and broadcast on CBS.

Colts vs Titans Preview

On Sunday, September 21, 2025, the Indianapolis Colts head to Nissan Stadium to take on the Tennessee Titans. The Colts are leading the AFC South with a 2-0 record. The Titans are still searching for their first win and sit at the bottom of the division with a 0-2 record. This game will be on CBS at 1:00 PM.

Daniel Jones leads the Colts with a projected 197 passing yards and one touchdown. Jonathan Taylor is expected to add 94.6 rushing yards. For the Titans, Cameron Ward is projected to throw for 213.2 yards and 1.2 touchdowns. Tony Pollard could contribute 79 rushing yards. Both teams aim to make a strong statement in this divisional game.

Tennessee Titans Home Game Preview

The Tennessee Titans are set to play at Nissan Stadium. They have yet to win a game this season, standing at 0-2. Their head coach, Brian Callahan, leads the team as they aim to turn things around in the AFC South.

Quarterback Cameron Ward is expected to throw for 213.2 yards and 1.2 touchdowns in the upcoming game. Running back Tony Pollard is projected to rush for 79 yards and score 0.4 touchdowns. Wide receiver Calvin Ridley is expected to lead the team with 61 receiving yards.

Last season, the Titans ranked 25th in scoring with 311 points. Their defense allowed 460 points, placing them 27th in that category. The team will need to improve on both ends to secure their first win this season.

Indianapolis Colts Look to Extend Winning Streak

The Indianapolis Colts are off to a strong start this season with a 2-0 record. Head coach Shane Steichen leads the team in the AFC South. They aim to continue their success on the road.

Quarterback Daniel Jones is set to throw for 197 yards and 1 touchdown in the upcoming game. Running back Jonathan Taylor is predicted to rush for 94.6 yards and score 0.7 touchdowns. Wide receiver Michael Pittman Jr. is projected to lead with 52.1 receiving yards.

Last season, the Colts ranked 16th in scoring with 377 points. Their defense allowed 427 points, placing them 23rd in that category. They will focus on maintaining their strong start this year.

Final Betting Pick

The Colts are a solid pick for the money line at -195. They have started the season strong with a 2-0 record. Their offense has been effective, scoring over 29 points in each of their last two games. Playing on the road has not been an issue for them, as they have shown resilience and consistency.

For the over/under prediction, taking the over at 43.5 seems reasonable. The Colts have been scoring well, while the Titans have allowed a lot of points at home. The Titans’ defense has struggled, giving up 33 points in their last home game. This combination suggests a game with plenty of scoring opportunities.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.