The New England Patriots will face off against the San Francisco 49ers at 4:05 ET on Sunday, September 29th. This matchup is being played at Levi’s Stadium in Santa Clara.

FOX is set to broadcast the week four non-conference matchup between the Patriots and 49ers at 4:05 ET. The 49ers are the heavy favorite with a point spread of -10 and money line odds of -526. The Patriots’ money line odds are +389, and the over/under line is 39.5 points. The game is being played at Levi’s Stadium in Santa Clara, CA.

• Date: Sunday, September 29th
• Time: 4:05 ET
• Location: Levi’s Stadium, Santa Clara
• TV: FOX

Patriots vs 49ers

After a 24-3 loss to the Jets, the Patriots are now 1-2 for the season. New England fell behind early, as the Jets led 7-0 after the 1st quarter. The Patriots managed a field goal in the 2nd quarter, but the Jets added another touchdown to make it 14-3 at halftime, and they put the game out of reach with another touchdown just before halftime.

New England went into the game as +6.5 point underdogs, and the Patriots’ tough day was capped off by not even coming close to covering the spread. The combined 27 points was well below the over/under line of 39 points.

Despite leading 14-0 after the 1st quarter, the 49ers still fell to the Rams 27-24, dropping their record to 1-2. San Francisco missed a chance to take a 28-14 lead in the 4th quarter when Jake Moody missed a 55-yard field goal with 2:48 remaining. The Rams capitalized, tying the game at 24 with 2:43 left in the 4th and then taking the lead for good with a field goal with five seconds left.

Heading into the 4th quarter, the 49ers were up 24-14, but the Rams outscored them 13-0 in the final period. This was a tough loss for the 49ers, as they were 6-point favorites on the road and missed a field goal that would have sealed the game in the 4th quarter.

Patriots Injury Report

• JaQuae Jackson – Knee (Out)
• Marte Mapu – Undisclosed (Out)
• Sidy Sow – Ankle (Questionable)
• Oshane Ximines – Knee (Out)
• Armon Watts – Undisclosed (Out)
• Sione Takitaki – Undisclosed (Out)
• Michael Jordan – Knee (Questionable)
• Chukwuma Okorafor – Commissioner Exempt List (Out)
• Kendrick Bourne – Undisclosed (Out)
• Ja’Whaun Bentley – Pectoral (Out)
• Cole Strange – Undisclosed (Out)
• Vederian Lowe – Knee (Questionable)
• Jake Andrews – Undisclosed (Out)
• Christian Barmore – Blood Clot (Out)

49ers Injury Report

• Kalia Davis – Knee (Out)
• Brock Purdy – Back (Questionable)
• Drake Jackson – Knee (Out)
• Elijah Mitchell – Hamstring (Out)
• Ambry Thomas – Forearm (Out)
• Deebo Samuel Sr. – Calf (Questionable)
• Dre Greenlaw – Achilles (Out)
• Jon Feliciano – Knee (Out)
• Javon Hargrave – Triceps (Out)
• Christian McCaffrey – Calf/achilles (Out)
• George Kittle – Hamstring (Questionable)
• Dee Winters – Ankle (Questionable)
• Ricky Pearsall – Back (Out)

Patriots Offense Breakdown

The Patriots’ offense struggled in their 24-3 loss to the Jets, managing just 11 first downs and 61 total yards passing. New England’s running game had only 15 attempts but averaged 5.2 yards per attempt, with Antonio Gibson leading the team with 29 yards.

Quarterback Jacoby Brissett was sacked seven times and finished with 98 yards passing. He completed 66% of his passes and had a passer rating of 80. Demario Douglas led the team with 69 receiving yards.

49ers Offense Breakdown

Despite a 27-24 loss to the Rams, the 49ers’ offense put up 25 first downs and 288 yards passing. They were unable to establish a strong running game, finishing with 137 yards on 34 attempts. Brock Purdy led the passing attack, going 22/30 for 292 yards and three touchdowns, with a passer rating of 137. He also ran for 41 yards.

Jordan Mason rushed for 77 yards to lead the team, while Jauan Jennings had a big game receiving, with 175 yards on 11 catches, including three touchdowns and a long reception of 34 yards. The 49ers also converted 54.5% of their third-down attempts.

Patriots Team Defense

In their 24-3 loss to the Jets, the Patriots’ defense allowed 267 passing yards, with two touchdowns coming through the air. Despite this, the Patriots didn’t allow a single completion in the game. The Patriots struggled to defend the run, allowing 133 rushing yards on 33 attempts. On third downs, the Jets converted 66.7% of their chances.

The Patriots did manage to get two sacks in the game, but they also allowed their quarterback to be hit 11 more times than the Jets’ quarterback. New England’s offense managed only a field goal in this one, and the Patriots allowed 400 total yards.

49ers Team Defense

In their 27-24 loss to the Rams, the 49ers’ defense allowed 198 passing yards and 98 rushing yards on 26 attempts (3.8 yards per attempt). They held the Rams to a 41.7% third-down conversion rate and recorded three sacks. Despite their efforts, the 49ers still came up short in their most recent game.

The 49ers’ defense did not allow a single completion in the passing game, but they did give up one passing touchdown. Additionally, the 49ers’ offense allowed 296 yards in the loss.

Patriots vs 49ers Trends

• The Patriots are 4-1 ATS in their last road games and 3-2 straight-up.
• Through their last three home contests, the 49ers offense has averaged 21 points per game while allowing an average of 25. San Francisco posted an overall record of 0-3 while going 0-3 ATS.
• Spanning across their last five games as the betting underdog, the Patriots have gone 3-1-1 vs the spread. Their overall record in these games was 2-3.
• Spanning across their last ten games as the betting favorite, the 49ers have gone 3-7 vs the spread. Their overall record in these games was 5-5.

Patriots vs 49ers Prediction

For this week four matchup between the Patriots and 49ers, we have the 49ers pulling off the upset by a score of 23-12. This is a great opportunity to take the 49ers to cover the spread, as they are 10-point favorites at home.

As for the over/under, with the line sitting at 39.5 points, our pick is to take the under, with a projected combined score of 35 points.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.