The Arizona Diamondbacks will take on the San Diego Padres on Friday, September 26, 2025, at 9:40 PM. The game will be held at PETCO Park in San Diego, CA. Expect mild weather with a light breeze under overcast clouds as these NL West teams meet on the field.

Diamondbacks vs. Padres Betting Prediction

• Money Line Prediction: Padres -146. The Padres have a strong home record of 49-29 and a better overall record than the Diamondbacks. Yu Darvish is pitching for the Padres, and despite his high ERA, the Padres’ pitching staff ranks 3rd in ERA this season.
• Over/Under Prediction: Under 7.5 (-107). The Padres have one of the best pitching staffs, ranking 3rd in ERA, and the Diamondbacks have struggled offensively in recent games, scoring only four runs in their last two games.

Team Trends

• The Arizona Diamondbacks have a road record of 37-41 this season.
• The San Diego Padres have a home record of 49-29 this season.
• Both the Diamondbacks and Padres have a 6-4 record in their last 10 games.
• Arizona Diamondbacks manager is Torey Lovullo, while the Padres are managed by Mike Schildt.
• The game will be played at PETCO Park in San Diego, CA, with overcast clouds expected.

Diamondbacks vs Padres Preview

The Arizona Diamondbacks head into PETCO Park with a record of 80-79. They sit third in the NL West and have hit a rough patch with two losses in a row. Their recent form shows a decent 6-4 in their last ten games. The Diamondbacks have yet to announce their starting pitcher, adding some uncertainty to their lineup.

The San Diego Padres hold a stronger position with an 87-72 record, ranking second in the division. They, too, have gone 6-4 in their last ten games but are coming off a loss. Yu Darvish is set to take the mound for the Padres. With an ERA of 5.51 and a WHIP of 1.15, Darvish will aim to secure a win for the home team. The game promises to be an exciting contest under the overcast skies of San Diego.

San Diego Padres: Key Players and Stats

The San Diego Padres have some strong hitters this season. Manny Machado leads the team with 26 home runs, ranking 18th in the league. He also has 93 RBIs, making him a key player for the Padres. Luis Arraez is another important hitter for the Padres. He has a batting average of .288, the highest on the team. Arraez has played 152 games, providing consistent performance throughout the season. Yu Darvish will be starting as the pitcher for the Padres. His ERA is 5.51, and he has a WHIP of 1.15. Darvish’s record is 4 wins and 5 losses, showing room for improvement.

Arizona Diamondbacks: Key Players and Team Stats

The Arizona Diamondbacks have a strong lineup this season. Geraldo Perdomo stands out with a batting average of .289. He has played 158 games and leads the team with 97 runs. Ketel Marte is another key player for the Diamondbacks. He has hit 26 home runs and has an on-base percentage of .376. Marte has contributed 84 runs in 124 games. Gabriel Moreno adds depth to the lineup with a batting average of .284. He has played 80 games and hit 9 home runs. Moreno has also driven in 40 RBIs for the team.

Final Betting Pick

The Padres look like a solid pick for the money line at -146. They have a strong home record of 49-29 and a better overall record than the Diamondbacks. Yu Darvish is starting for the Padres, and while his ERA is high, the team ranks 3rd in ERA this season. This suggests that the Padres’ pitching staff can keep the Diamondbacks’ offense in check.

For the over/under, going under 7.5 seems reasonable. The Padres have a top pitching staff, and the Diamondbacks have struggled offensively, scoring only four runs in their last two games. Additionally, the Diamondbacks have a losing road record, which might make it harder for them to score against a strong Padres pitching lineup. This combination points to a lower-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.