The St. Louis Cardinals will take on the San Francisco Giants on Tuesday, September 23, 2025, at 9:45 PM. Both teams share a record of 77-80 and are ranked fourth in their respective divisions. The game will be held at Oracle Park in San Francisco, CA, with clear skies and a light breeze expected. Tune in to FDSMW to catch the action.

Cardinals vs. Giants Betting Prediction

• Money Line Prediction: Cardinals +165. The Cardinals have won their last two games and recently beat the Giants. The Giants have struggled at home, going 38-38 this season.
• Over/Under Prediction: Over 7.5 (-107). Both teams have shown the ability to score runs, with the Cardinals winning 6-5 in their last meeting. The Giants have given up 137 home runs this season, which is the most in the league.

Team Trends

• The St. Louis Cardinals have a road record of 33-43 this season.
• The San Francisco Giants have a home record of 38-38 this season.
• In their last game, the St. Louis Cardinals won 6-5 against the San Francisco Giants.
• The San Francisco Giants have lost 8 of their last 10 games.
• The St. Louis Cardinals are currently on a 2-game winning streak.

Cardinals vs Giants Preview

The St. Louis Cardinals and San Francisco Giants are set to meet at Oracle Park. Both teams have the same record of 77-80 and are fourth in their divisions. The Cardinals have won their last two games, while the Giants have lost one. Recent form shows the Cardinals at 5-5 in their last ten games, and the Giants struggling at 2-8.

Andre Pallante will start for the Cardinals. He has a 5.29 ERA and a 1.44 WHIP this season. Logan Webb will pitch for the Giants. He has a 3.27 ERA and a 1.24 WHIP. Webb has a better win-loss record at 14-11 compared to Pallante’s 6-15. This game will be played under clear skies with a light breeze, making for a pleasant evening of baseball.

Giants’ Lineup and Pitching Preview

The San Francisco Giants have some strong hitters in their lineup. Rafael Devers leads the team with 33 home runs, ranking 10th in the league. Willy Adames and Matt Chapman also contribute with 28 and 21 home runs, respectively. On the pitching side, Logan Webb is the starting pitcher for the Giants. Webb has an ERA of 3.27 and a WHIP of 1.24. His record stands at 14 wins and 11 losses. Team batting stats show the Giants with a batting average of .234, placing them 19th in the league. They rank 17th in on-base percentage at .310. Their slugging percentage is .384, which ranks 23rd.

Cardinals’ Hitting and Pitching Insights

The St. Louis Cardinals have several key players in their lineup. Willson Contreras leads with 20 home runs and a batting average of .257. Alec Burleson follows with a .293 batting average and 18 home runs. Andre Pallante is the starting pitcher for the Cardinals. He has an ERA of 5.29 and a WHIP of 1.44. His record is 6 wins and 15 losses this season. The Cardinals rank 13th in team batting average at .245. Their on-base percentage is .314, placing them 14th. They have hit 144 home runs, ranking 24th in the league.

Final Betting Pick

The Cardinals are a good pick for the money line at +165. They have won their last two games, including a win over the Giants. On the road, they have a record of 33-43, showing they can compete away from home.

Choosing the over 7.5 runs is a solid choice. The Cardinals and Giants both have the ability to score runs. The Giants have given up the most home runs in the league this season, which could lead to a high-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.