Chicago Cubs vs Cincinnati Reds MLB Betting Prediction
PublishedSeptember 20, 2025,            Posted By: Maria Uebelhor
Last updated:September 20, 2025 ,

MLB Chicago Cubs vs Cincinnati Reds Prediction 9/20

The Chicago Cubs will visit the Cincinnati Reds on Saturday, September 20, 2025, at 6:40 PM. The game will take place at Great American Ball Park in Cincinnati, OH. The Cubs have a record of 88-66, while the Reds hold a 78-76 record. The Cubs are currently on a two-game losing streak, while the Reds have won their last three games. The weather forecast predicts overcast clouds with calm winds. The game will be broadcast on MARQ.

Cubs vs. Reds Betting Prediction

  • Money Line Prediction: Cincinnati Reds -107. The Reds have a strong home record of 42-34 and are on a 3-game winning streak. They have also won the last two games against the Cubs.
  • Over/Under Prediction: Under 9.0 (-106). Both teams have solid pitching, and the last game between these teams ended with a total of 8 runs.

Team Trends

  • The Chicago Cubs have a road record of 42-37 this season.
  • The Cincinnati Reds have a home record of 42-34 this season.
  • The Cubs have lost their last two games against the Reds, with scores of 7-4 and 1-0.
  • The Reds are currently on a three-game winning streak.
  • The game is set to take place at Great American Ball Park, with overcast clouds expected.

Cubs vs Reds Preview

The Chicago Cubs are set to play against the Cincinnati Reds at Great American Ball Park. The Cubs have an 88-66 record and are in second place in their division. They have hit a rough patch with a two-game losing streak. Meanwhile, the Reds, with a 78-76 record, are in third place and have been doing well lately, winning their last three games.

Javier Assad will start for the Cubs. He has a 4.23 ERA and a WHIP of 1.30. Zack Littell will pitch for the Reds. Littell has a 3.86 ERA and a WHIP of 1.11. The game will be broadcast on MARQ, and the weather is expected to be overcast with calm winds.

Reds’ Key Players and Stats

The Cincinnati Reds have some standout hitters this season. Elly De La Cruz leads the team with 20 home runs and 100 runs. His batting average is .262, and he has played 154 games. Spencer Steer has also contributed with 20 home runs. He has a batting average of .243 and has played 138 games. Matt McLain adds to the lineup with 15 home runs and a batting average of .223. On the mound, Zack Littell will start for the Reds. He has a 3.86 ERA and a WHIP of 1.11. His record stands at 9 wins and 8 losses.

Chicago Cubs: Key Players and Stats

The Chicago Cubs have some strong hitters this season. Seiya Suzuki leads with 27 home runs and 91 RBIs. He has a batting average of .243 in 143 games. Michael Busch adds power with 29 home runs and a .256 average over 147 games. Dansby Swanson is another key player for the Cubs. He has played 151 games, hitting 23 home runs. His batting average is .249, and he leads the team with 82 runs. On the mound, Javier Assad will start for the Cubs. He has an ERA of 4.23 and a WHIP of 1.30. His record is 3 wins and 1 loss.

Final Betting Pick

The Cincinnati Reds are a strong pick for the money line at -107. They have a solid home record of 42-34 and are on a 3-game winning streak. The Reds have also won their last two games against the Cubs, showing they can perform well against this opponent.

The under 9.0 total is a good choice due to the solid pitching from both teams. The last game between these teams ended with a total of 8 runs. With pitchers like Zack Littell for the Reds and Javier Assad for the Cubs, the game is likely to be low-scoring again.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.