Chicago Cubs vs Cincinnati Reds MLB Betting Prediction
PublishedSeptember 21, 2025,            Posted By: Maria Uebelhor
Last updated:September 21, 2025 ,

MLB Chicago Cubs vs Cincinnati Reds Prediction 9/21

The Chicago Cubs are set to play against the Cincinnati Reds on Sunday, September 21, 2025, at 1:40 PM. The game will take place at Great American Ball Park in Cincinnati, OH. Fans can catch the action on FDSOH, with the weather forecast predicting a mild day and broken clouds.

Cubs vs. Reds Betting Prediction

  • Money Line Prediction: Cincinnati Reds -112. The Reds are on a four-game win streak and have been strong at home with a 43-34 record. The Cubs have lost three in a row, all against the Reds.
  • Over/Under Prediction: Under 9.0 (-115). Both starting pitchers have solid ERAs, with Taillon at 3.93 and Abbott at 2.88. Recent games between these teams have seen low scores.

Team Trends

  • The Chicago Cubs have a road record of 42-38 this season.
  • The Cincinnati Reds have won their last four games.
  • In their last game, the Reds won 6-3 against the Cubs at home.
  • The Reds have a home record of 43-34 this season.
  • The Cubs are currently on a three-game losing streak.

Cubs vs Reds Preview

The Chicago Cubs will play the Cincinnati Reds at Great American Ball Park. The Cubs are currently second in their division with a record of 88-67. They are looking to break a three-game losing streak. Jameson Taillon will start for the Cubs. He has a 3.93 ERA and a WHIP of 1.09.

The Reds have a record of 79-76 and are third in their division. They have won their last four games. Andrew Abbott will take the mound for the Reds. He has a 2.88 ERA and a WHIP of 1.15. Both teams have gone 6-4 in their last ten games. Fans can expect an exciting afternoon of baseball.

Cincinnati Reds: Key Players and Stats

The Cincinnati Reds have some strong hitters this season. Elly De La Cruz leads the team in runs and RBIs, with 100 runs and 83 RBIs. Spencer Steer has hit the most home runs on the team with 21, ranking 22nd in the league. Andrew Abbott is set to start for the Reds. His ERA is 2.88, and he has a WHIP of 1.15. Abbott has a record of 9 wins and 7 losses. The team batting average is .245, which ranks 12th in the league. Their on-base percentage is also .315, placing them 12th as well. The Reds have hit 161 home runs this season, ranking 19th in the league.

Chicago Cubs: Strong Performances and Stats

The Chicago Cubs have some standout players this season. Seiya Suzuki has hit 27 home runs, placing him 16th in the league. He also leads the team with 91 RBIs. Michael Busch is another key player with 30 home runs, ranking 13th in the league. Dansby Swanson and Nico Hoerner contribute to the Cubs’ success. Swanson has played 152 games and scored 82 runs, leading the team. Hoerner has a batting average of .301, which is the highest on the team. Jameson Taillon will start as the pitcher for the Cubs. He has an ERA of 3.93 and a WHIP of 1.09. Taillon’s record stands at 10 wins and 6 losses.

Final Betting Pick

The Cincinnati Reds are on a roll with a four-game win streak. Their recent success includes three wins against the Cubs. At home, the Reds have a solid 43-34 record, which gives them an edge in this game. Andrew Abbott, the Reds’ starting pitcher, has an impressive ERA of 2.88, which could keep the Cubs’ hitters in check.

On the other hand, the Cubs have struggled recently, losing their last three games, all against the Reds. Jameson Taillon, the Cubs’ starter, has a decent ERA of 3.93, but the Reds’ lineup has managed to find ways to score. Recent games between these teams have been low-scoring, making the under 9.0 a reasonable prediction. The Reds’ current form and home advantage make them a strong pick on the money line.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.