The Chicago White Sox take on the Cleveland Guardians on Friday, September 12, 2025, at Progressive Field. The game starts at 7:10 PM and will be shown on CLEG. The weather forecast predicts a warm day with a light breeze and clear skies. The White Sox come in with a record of 57-90, while the Guardians hold a record of 75-71.

White Sox vs. Guardians Betting Prediction

• Money Line Prediction: Cleveland Guardians -169. The Guardians have a better home record and a solid division record. Their starting pitcher, Tanner Bibee, has more wins this season compared to Martín Pérez of the White Sox.
• Over/Under Prediction: Under 7.5 (-104). Both teams have shown strong pitching performances recently, and the Guardians have a lower ERA, suggesting a low-scoring game.

Team Trends

• The Chicago White Sox have a road record of 25-47 this season.
• The Cleveland Guardians hold a home record of 38-34 this season.
• The Chicago White Sox are on a 2-game winning streak and have won 8 of their last 10 games.
• The Cleveland Guardians are on a 1-game winning streak and have won 7 of their last 10 games.
• The game will be played at Progressive Field in Cleveland, with a forecast of clear skies and a light breeze.

White Sox vs Guardians Preview

The Chicago White Sox will visit the Cleveland Guardians at Progressive Field. The White Sox have a record of 57-90 and rank 5th in their division. They have been performing well lately, with an 8-2 record in their last 10 games. Martín Pérez will take the mound for the White Sox. He has an ERA of 3.15 and a WHIP of 1.07.

The Cleveland Guardians hold a 75-71 record and are 2nd in their division. They are on a 1-game winning streak and have gone 7-3 in their last 10 games. Tanner Bibee will start for the Guardians. His ERA is 4.69, and his WHIP is 1.29. The game starts at 7:10 PM, and the weather will be warm with clear skies.

Guardians’ Key Players and Insights

José Ramírez is a standout for the Cleveland Guardians. He has played 142 games with a batting average of .285. He leads the team in home runs with 28 and has scored 91 runs.

Kyle Manzardo is another important player for the Guardians. In 126 games, he holds a batting average of .240. Manzardo is second on the team with 26 home runs and has 44 runs scored.

On the mound, Tanner Bibee will start for the Guardians. His ERA is 4.69, and he has a WHIP of 1.29. Bibee has a win-loss record of 9-11 this season.

White Sox Ready for Guardians Challenge

The Chicago White Sox have some strong hitters this season. Lenyn Sosa stands out with a batting average of .265 over 127 games. He leads the team with 20 home runs and has 67 RBIs. Miguel Vargas is another key player for the White Sox. He has played 124 games with a batting average of .233. Vargas has hit 14 home runs and scored 71 runs. On the pitching side, Martín Pérez will take the mound for the White Sox. He holds an ERA of 3.15 and a WHIP of 1.07. His win-loss record is 1-4 this season.

Final Betting Pick

The Cleveland Guardians are favored on the money line at -169. They have a strong home record of 38-34, which gives them an edge. Tanner Bibee, their starting pitcher, has nine wins this season, which is more than Martín Pérez of the White Sox, who has only one win. This suggests that Bibee might have better support from his team.

The prediction for the total runs is under 7.5. Both teams have shown good pitching lately. The Guardians have a lower ERA of 3.86, which ranks them 9th in the league. This indicates they can limit the White Sox’s scoring opportunities. The White Sox have also struggled on the road with a 25-47 record, which might make it hard for them to score many runs.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.